Keating J C, Giljum K, Menke J M, Lonczak R S, Meeker W C
J Manipulative Physiol Ther. 1985 Dec;8(4):229-38.
If chiropractic is to develop as a clinical science, it must develop an experimental data-base. Despite numerous continuing obstacles, a growing segment of the profession is advocating chiropractic clinical trials. However, the large-scale control-group clinical-experimental designs which have most frequently been recommended are usually beyond the economic means of chiropractic institutions. Moreover, such designs are impractical in many ways for the chiropractic field-doctor who wishes to integrate the roles of scientist and practitioner. Time-series experimental (and case study) designs offer practical and economical alternatives for the DC, whether inter, solo-practitioner, or academic researcher. Several types of time-series designs are described, published examples from related health-care literature are noted, and the role of time-series research in furthering the goals of chiropractic research are reviewed. Ethical considerations in clinical research are briefly noted.
如果整脊疗法要发展成为一门临床科学，就必须建立一个实验数据库。尽管仍存在诸多持续的障碍，但该行业中越来越多的人主张进行整脊疗法临床试验。然而，最常被推荐的大规模对照组临床实验设计通常超出了整脊疗法机构的经济承受能力。此外，对于希望将科学家和从业者角色结合起来的整脊疗法现场医生来说，这种设计在很多方面都不切实际。时间序列实验（和案例研究）设计为整脊疗法医生提供了实用且经济的替代方案，无论他们是从事联合执业、个体执业还是学术研究。本文描述了几种类型的时间序列设计，列举了相关医疗保健文献中已发表的示例，并回顾了时间序列研究在推进整脊疗法研究目标方面的作用。还简要提及了临床研究中的伦理考量。
