We report a case of a 35-year-old woman with persistent gastroesophageal reflux disease (GERD) despite lifestyle modification and medical therapy. Endoscopy revealed a squamous papilloma in the distal esophagus, a rare benign lesion linked to chronic mucosal irritation. The lesion was excised, and histopathology confirmed squamous papilloma without dysplasia. This case underscores the importance of endoscopic evaluation in patients with uncontrolled reflux and highlights the potential link between GERD and benign esophageal neoplasms.