Mondal Himel, Varikasuvu Seshadri Reddy, Sarangi Pradosh Kumar
Physiology, All India Institute of Medical Sciences, Deoghar, Jharkhand, IND.
Biochemistry, All India Institute of Medical Sciences, Deoghar, Jharkhand, IND.
Cureus. 2025 Jul 10;17(7):e87690. doi: 10.7759/cureus.87690. eCollection 2025 Jul.
Systematic reviews and meta-analyses are central to evidence-based medicine, but their validity depends on the quality and completeness of the included randomized controlled trials (RCTs). Despite the existence of guidelines such as the Consolidated Standards of Reporting Trials (CONSORT), inadequate reporting remains a widespread issue, often impeding data extraction and synthesis. Common gaps include the type of RCT, randomization methods, group-wise sample sizes, dropout details, and primary outcome data. Poor reporting threatens the transparency, reproducibility, and utility of clinical research, ultimately compromising the reliability of systematic reviews and the clinical guidelines based on them. To address this, strict adherence to reporting standards must be enforced by journals, reviewers, and funding bodies. Researchers should be encouraged to share tabulated core trial information in public repositories. Educational efforts targeting early-career researchers and stricter accountability mechanisms are crucial. Incomplete reporting must be recognized as a serious obstacle to evidence synthesis and treated as a significant threat to the scientific enterprise.
系统评价和荟萃分析是循证医学的核心,但它们的有效性取决于纳入的随机对照试验(RCT)的质量和完整性。尽管存在诸如《试验报告统一标准》(CONSORT)等指南,但报告不充分仍然是一个普遍问题,常常阻碍数据提取和综合。常见的缺失内容包括RCT的类型、随机化方法、组间样本量、失访细节以及主要结局数据。报告不佳会威胁临床研究的透明度、可重复性和实用性,最终损害系统评价以及基于这些评价的临床指南的可靠性。为解决这一问题,期刊、审稿人和资助机构必须严格执行报告标准。应鼓励研究人员在公共知识库中分享表格形式的核心试验信息。针对早期职业研究人员的教育工作和更严格的问责机制至关重要。必须认识到报告不完整是证据综合的严重障碍,并将其视为对科学事业的重大威胁。