一例原发性冷凝集素介导的溶血性贫血经类固醇成功治疗的病例。
A Case of Primary Cold Agglutinin-Mediated Hemolytic Anemia Successfully Treated with Steroids.
作者信息
Raja Thayani, Mayurathan Pakkiyaretnam, Sabrina Sithy
机构信息
University Medical Unit, Teaching Hospital, Batticaloa, LKA.
Clinical Sciences, Faculty of Healthcare Sciences, Eastern University of Sri Lanka, Batticaloa, LKA.
出版信息
Cureus. 2025 Jul 10;17(7):e87669. doi: 10.7759/cureus.87669. eCollection 2025 Jul.
Cold agglutinin disease (CAD) is an uncommon subtype of autoimmune hemolytic anemia (AIHA). Cold agglutinin syndrome (CAS) may occur secondary to infections, autoimmune disorders, or malignancies, which must be ruled out to establish a diagnosis of primary CAD. Typically, cold autoimmune hemolytic anemia (cAIHA) is unresponsive to corticosteroid therapy. However, we report a case of a 69-year-old male patient with primary CAD who was successfully treated with corticosteroids. The patient demonstrated marked clinical improvement and normalization of hemolytic markers following treatment with prednisone.
冷凝集素病（CAD）是自身免疫性溶血性贫血（AIHA）的一种罕见亚型。冷凝集素综合征（CAS）可能继发于感染、自身免疫性疾病或恶性肿瘤，在诊断原发性CAD时必须排除这些因素。通常，冷凝集素自身免疫性溶血性贫血（cAIHA）对皮质类固醇治疗无反应。然而，我们报告了一例69岁男性原发性CAD患者，经皮质类固醇治疗成功。该患者在使用泼尼松治疗后临床症状明显改善，溶血指标恢复正常。
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