Böhm Allan, Lucka Julia, Segev Amitai, Kollarova Marta, Toth Stefan, Jajcay Nikola, Bezak Branislav
Premedix Academy, Bratislava, Slovakia.
Third Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Eur J Case Rep Intern Med. 2025 Jul 23;12(8):005420. doi: 10.12890/2025_005420. eCollection 2025.
Untreated thyroid disorders may precipitate heart failure (HF) decompensation. Assessment of cardiac filling pressures may aid in the early detection and prevention of clinical decompensation. Therapy guided by monitoring of cardiac filling pressures has been shown to improve quality of life and survival and reduce hospitalizations of individuals with HF. We have developed a non-invasive method to assess left ventricular filling pressures (LVFP) by analysing the photoplethysmography signal with Seeling HeartCore technology (Seerlinq, Bratislava, Slovakia).
A 99-year-old female visited the clinic for a routine cardiac check-up. Laboratory investigations showed elevated NTproBNP and moderately elevated high sensitive troponin T. HeartCore algorithm indicated elevated LVFP. As part of the evaluation of worsening of sub-clinical HF, extended laboratory tests revealed low thyroid-stimulating hormone with high free thyroxine levels indicating increased thyroid function. The endocrinologist diagnosed hyperthyroidism with multinodular goitre and prescribed thiamazole. To prevent progression to clinical HF decompensation, the dose of furosemide was increased. At 4 months, during scheduled cardiac follow-up, the patient was clinically doing well, without any signs or symptoms of HF.
Remote monitoring devices that track pressures in the pulmonary artery require invasive implantation and are associated to potential complications. The high cost of these devices presents a significant barrier to widespread use. SEERLINQ is a novel system for remote haemodynamic monitoring based on non-invasive assessment of LVFP, presenting a promising alternative to current invasive methods.
This case underscores the potential benefits of this technology in the early recognition of pre-clinical deterioration and its implementation for remote home monitoring in patients with HF.
Untreated thyroid disorders in patients with heart failure (HF) can exacerbate signs and symptoms of HF.Left ventricular filling pressure (LVFP) rises 3-4 weeks before HF symptoms. Echocardiographic assessment of LVFP can be challenging in patients with atrial fibrillation or paced rhythms.Photoplethysmography-based analysis could be utilized to assess LVFP, enabling remote monitoring of HF patients and potentially preventing HF decompensation and hospitalization.
未经治疗的甲状腺疾病可能会促使心力衰竭（HF）失代偿。评估心脏充盈压可能有助于早期发现和预防临床失代偿。有研究表明，以心脏充盈压监测为指导的治疗可改善生活质量、提高生存率并减少HF患者的住院次数。我们开发了一种非侵入性方法，通过使用Seeling HeartCore技术（Seerlinq，斯洛伐克布拉迪斯拉发）分析光电容积脉搏波信号来评估左心室充盈压（LVFP）。
一名99岁女性到诊所进行常规心脏检查。实验室检查显示N末端B型利钠肽原（NTproBNP）升高，高敏肌钙蛋白T中度升高。HeartCore算法显示LVFP升高。作为亚临床HF恶化评估的一部分，进一步的实验室检查显示促甲状腺激素水平低，游离甲状腺素水平高，表明甲状腺功能亢进。内分泌科医生诊断为多结节性甲状腺肿伴甲状腺功能亢进，并开具了甲巯咪唑。为防止进展为临床HF失代偿，增加了呋塞米的剂量。4个月后，在定期心脏随访期间，患者临床情况良好，无任何HF体征或症状。
追踪肺动脉压力的远程监测设备需要进行侵入性植入，且存在潜在并发症。这些设备的高成本是广泛应用的重大障碍。SEERLINQ是一种基于LVFP非侵入性评估的新型远程血流动力学监测系统，是当前侵入性方法的一个有前景的替代方案。
本病例强调了该技术在早期识别临床前恶化及其在HF患者远程家庭监测中的应用方面的潜在益处。
心力衰竭（HF）患者未经治疗的甲状腺疾病会加重HF的体征和症状。HF症状出现前3 - 4周左心室充盈压（LVFP）会升高。对于心房颤动或起搏心律的患者，通过超声心动图评估LVFP可能具有挑战性。基于光电容积脉搏波的分析可用于评估LVFP，实现对HF患者的远程监测，并有可能预防HF失代偿和住院。
