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用于亚组分析的异质性功能回归

Heterogeneous Functional Regression for Subgroup Analysis.

作者信息

Zhou Yeqing, Jiang Fei

机构信息

School of Mathematical Sciences, School of Economics and Management, and Key Laboratory of Intelligent Computing and Applications, Tongji University, Shanghai, China.

Department of Epidemiology and Biostatistics, The University of California, San Francisco, San Francisco, CA.

出版信息

J Comput Graph Stat. 2024 Dec 20. doi: 10.1080/10618600.2024.2414113.

DOI:10.1080/10618600.2024.2414113
PMID:40786560
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12330897/
Abstract

With ever increasing number of features of modern datasets, data heterogeneity is gradually becoming the norm rather than the exception. Whereas classical regressions usually assume all the samples follow a common model, it becomes imperative to identify the heterogeneous relationship in different subsamples. In this article, we propose a new approach to model heterogeneous functional regression relations. We target at the association between a response and a predictor, whose relationship can vary across underlying subgroups and is modeled as an unknown functional of an auxiliary predictor. We introduce a procedure which performs simultaneous parameter estimation and subgroup identification through a fusion type group-wise penalization. We establish the statistical guarantees in terms of non-asymptotic convergence of the parameter estimation. We also establish the oracle property and asymptotic normality of the estimators. We carry out intensive simulations, and illustrate with a new dataset from an Alzheimer's disease study. Supplementary materials for this article are available online.

摘要

随着现代数据集的特征数量不断增加,数据异质性正逐渐成为常态而非例外。经典回归通常假设所有样本都遵循一个共同模型,因此识别不同子样本中的异质关系变得势在必行。在本文中,我们提出了一种新方法来对异质函数回归关系进行建模。我们针对响应变量和预测变量之间的关联,其关系可能在不同的潜在子组中有所不同,并被建模为辅助预测变量的未知函数。我们引入了一种通过融合型组内惩罚进行同时参数估计和子组识别的方法。我们在参数估计的非渐近收敛方面建立了统计保证。我们还建立了估计量的神谕性质和渐近正态性。我们进行了大量模拟,并以一项阿尔茨海默病研究的新数据集进行了说明。本文的补充材料可在线获取。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc2/12330897/aeb34afa13ac/nihms-2032539-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc2/12330897/06a4e23b56fd/nihms-2032539-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc2/12330897/e3da8a5cb26b/nihms-2032539-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc2/12330897/aeb34afa13ac/nihms-2032539-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc2/12330897/06a4e23b56fd/nihms-2032539-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc2/12330897/e3da8a5cb26b/nihms-2032539-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc2/12330897/aeb34afa13ac/nihms-2032539-f0003.jpg

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本文引用的文献

1
Assessing the Most Vulnerable Subgroup to Type II Diabetes Associated with Statin Usage: Evidence from Electronic Health Record Data.评估他汀类药物使用相关的II型糖尿病最脆弱亚组:来自电子健康记录数据的证据。
J Am Stat Assoc. 2023;118(543):1488-1499. doi: 10.1080/01621459.2022.2157727. Epub 2023 Jan 20.
2
Causal interaction trees: Finding subgroups with heterogeneous treatment effects in observational data.因果交互树:在观察性数据中找到具有异质治疗效果的亚组。
Biometrics. 2022 Jun;78(2):624-635. doi: 10.1111/biom.13432. Epub 2021 Feb 11.
3
Subgroup analysis in the heterogeneous Cox model.
异质性Cox模型中的亚组分析。
Stat Med. 2021 Feb 10;40(3):739-757. doi: 10.1002/sim.8800. Epub 2020 Nov 9.
4
NUTMEG: Open Source Software for M/EEG Source Reconstruction.肉豆蔻:用于脑电/脑磁图源重建的开源软件。
Front Neurosci. 2020 Aug 25;14:710. doi: 10.3389/fnins.2020.00710. eCollection 2020.
5
Neuroanatomical spread of amyloid β and tau in Alzheimer's disease: implications for primary prevention.阿尔茨海默病中β淀粉样蛋白和tau蛋白的神经解剖学传播:对一级预防的启示
Brain Commun. 2020;2(1):fcaa007. doi: 10.1093/braincomms/fcaa007. Epub 2020 Feb 6.
6
Desikan-Killiany-Tourville Atlas Compatible Version of M-CRIB Neonatal Parcellated Whole Brain Atlas: The M-CRIB 2.0.与Desikan-Killiany-Tourville图谱兼容版本的M-CRIB新生儿分区全脑图谱:M-CRIB 2.0
Front Neurosci. 2019 Feb 5;13:34. doi: 10.3389/fnins.2019.00034. eCollection 2019.
7
Imaging the evolution and pathophysiology of Alzheimer disease.阿尔茨海默病的演变和病理生理学成像。
Nat Rev Neurosci. 2018 Nov;19(11):687-700. doi: 10.1038/s41583-018-0067-3.
8
Subthreshold Amyloid Predicts Tau Deposition in Aging.亚阈值淀粉样蛋白可预测衰老中的 Tau 沉积。
J Neurosci. 2018 May 9;38(19):4482-4489. doi: 10.1523/JNEUROSCI.0485-18.2018. Epub 2018 Apr 23.
9
The nonlinear relationship between cerebrospinal fluid Aβ42 and tau in preclinical Alzheimer's disease.临床前阿尔茨海默病中脑脊液Aβ42与tau之间的非线性关系。
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10
Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals.结构束改变可预测淀粉样蛋白阳性老年个体下游tau蛋白的积累。
Nat Neurosci. 2018 Mar;21(3):424-431. doi: 10.1038/s41593-018-0070-z. Epub 2018 Feb 5.