Osiecki Andrzej, Sarwiński Krzysztof, Gąsior Jakub, Kochman Wacław, Michałkiewicz Dariusz, Pawlak Agnieszka
Department of Cardiovascular Diseases, Centre of Postgraduate Medical Education, Warsaw, Poland.
Department of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, Warsaw, Poland.
Caspian J Intern Med. 2025 May 15;16(3):405-416. doi: 10.22088/cjim.16.3.405. eCollection 2025 Summer.
Tako-tsubo syndrome (TTs) is relatively young cardiovascular entity, being initially described in the 1991 by dr Hikaru Sato. Most patients with TTs are admitted to the hospital with the suspicion of acute coronary syndrome or present signs and symptoms typical for acute heart failure. Atrial arrhythmias are thought to complicate almost 10% of all TTs cases. The most prevalent among them is atrial fibrillation (AF). Our aim in this study was to systematically evaluate results of observational studies to assess the incidence and prognostic relevance of supraventricular tachyarrhythmias in TTs patients.
We performed systematic search of the Cochrane Central Register of Controlled Trials, PubMed, and EMBASE databases for research evaluating the incidence and prognostic relevance of atrial fibrillation(AF)/atrial flutter(AFl)/atrial tachycardia(AT) in patients hospitalized due to TTs. Odd ratio (OR) with a 95% confidence interval (CI) was estimated using a random effect model.
10 studies comprising 4183 patients were included. The incidence of atrial arrhythmias ranged between 7% to 33%. In our research, supraventricular tachyarrhythmias were associated with significant increased risk for all-cause death (OR 2.99; 95% CI: 2.36- 3.80; p < 0.05), intra-hospital mortality (OR 2.46; 95% CI: 1.30 - 4.63; p < 0.05) and long-term mortality (OR 3.01 95% CI: 2.33- 3.90; p < 0.05).
Our meta-analysis suggests that atrial arrhythmias are associated with an elevated risk for short and long-term adverse outcomes in patients with TTs.
应激性心肌病（TTs）是一种相对较新的心血管疾病，最初由佐藤光医生于1991年描述。大多数TTs患者因疑似急性冠状动脉综合征入院，或出现急性心力衰竭的典型症状和体征。房性心律失常被认为在所有TTs病例中使近10%的病情复杂化。其中最常见的是心房颤动（AF）。我们在本研究中的目的是系统评价观察性研究的结果，以评估TTs患者室上性快速性心律失常的发生率及预后相关性。
我们对Cochrane对照试验中心注册库、PubMed和EMBASE数据库进行了系统检索，以查找评估因TTs住院患者心房颤动（AF）/心房扑动（AFl）/房性心动过速（AT）的发生率及预后相关性的研究。使用随机效应模型估计比值比（OR）及95%置信区间（CI）。
纳入了10项研究，共4183例患者。房性心律失常的发生率在7%至33%之间。在我们的研究中，室上性快速性心律失常与全因死亡风险显著增加相关（OR 2.99；95%CI：2.36 - 3.80；p<0.05）、院内死亡率（OR 2.46；95%CI：1.30 - 4.63；p<0.05）和长期死亡率（OR 3.01，95%CI：2.33 - 3.90；p<0.05）。
我们的荟萃分析表明，房性心律失常与TTs患者短期和长期不良结局风险升高相关。
