Noori Noor Mohammad, Teimouri Alireza, Basham Ayoub, Rajaei Shahrokh
Children and Adolescents Health Research Center, Research Institute of Cellular and Molecular Science in Infectious Disease, Zahedan University of Medical Science, Zahedan, Iran.
Student Research Committee, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Caspian J Intern Med. 2025 Jun 23;16(3):536-541. doi: 10.22088/cjim.16.3.536. eCollection 2025 Summer.
Hypothyroidism and leptin deficiency are two common endocrinopathies in β-thalassemia major patients (β-TM). Changes in leptin levels may lead to changes in thyroid hormone levels in thalassemia patients through suppression of the hypothalamus-pituitary-thyroid axis. Hence, we aimed to evaluate their correlation in β-TM patients.
A cross-sectional study was conducted on transfusion dependent β-thalassemia patients receiving chelation treatment between 2018 and 2019. Tri-iodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH), and leptin were measured for each participant. Data analyzed by SPSS, p< 0.05 was considered as significant.
One hundred and twenty-six β-TM patients aged between 10 and 30 years old participated in the study, including 55 (43.7%) females and 71(56.3%) males. TSH abnormality was prevalent among 13 (23.6%) females and 10(14.1%) males. Leptin level was significantly lower in males (6.65±7.27 VS 2.41±2.79, p<0.01). TSH was correlated with leptin in all (r=0.393, p<0.01), females (r=0.387, p<0.01), males (r=0.387, p<0.01), adolescents (r=0.512, p<0.01), young adults (r=0.287, P=0.01), underweights (r=0.483, p<0.01) and normal weight (r=0.301, P=0.03) thalassemia patients. T4 was correlated with leptin in all (r=0.201, p=0.02), females (r=0.281, P=0.03), males (r=0.281, P=0.03), and adolescents (r=0.280, P=0.03) β-TM patients. T3 did not correlate with leptin in all groups of the patients.
In summary, leptin levels were significantly lower in males, and TSH abnormality was common in both genders. Therefore, screening for endocrine issues may benefit these people. Furthermore, leptin exhibited a correlation with TSH and T4. This may support the role of leptin on thyroid function in β-TM patients.
甲状腺功能减退和瘦素缺乏是重型β地中海贫血患者（β-TM）中两种常见的内分泌疾病。瘦素水平的变化可能通过抑制下丘脑-垂体-甲状腺轴导致地中海贫血患者甲状腺激素水平的变化。因此，我们旨在评估它们在β-TM患者中的相关性。
对2018年至2019年期间接受螯合治疗的输血依赖型β地中海贫血患者进行了一项横断面研究。测量了每位参与者的三碘甲状腺原氨酸（T3）、甲状腺素（T4）、促甲状腺激素（TSH）和瘦素。通过SPSS分析数据，p<0.05被认为具有统计学意义。
126名年龄在10至30岁之间的β-TM患者参与了该研究，其中55名（43.7%）为女性，71名（56.3%）为男性。TSH异常在13名（23.6%）女性和10名（14.1%）男性中普遍存在。男性的瘦素水平显著较低（6.65±7.27对2.41±2.79，p<0.01）。在所有患者（r=0.393，p<0.01）、女性（r=0.387，p<0.01）、男性（r=0.387，p<0.01）、青少年（r=0.512，p<0.01）、青年（r=0.287，P=0.01）、体重过轻（r=0.483，p<0.01）和体重正常（r=0.301，P=0.03）的地中海贫血患者中，TSH与瘦素相关。在所有患者（r=0.201，p=0.02）、女性（r=0.281，P=0.03）、男性（r=0.281，P=0.03）和青少年（r=0.280，P=0.03）的β-TM患者中T4与瘦素相关。在所有患者组中，T3与瘦素均无相关性。
总之，男性的瘦素水平显著较低，TSH异常在两性中都很常见。因此，筛查内分泌问题可能对这些人有益。此外，瘦素与TSH和T4存在相关性。这可能支持瘦素在β-TM患者甲状腺功能中的作用。
