Wang Jiaolong, Gao Ning, Wei Junchao, Liao Lan
School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Jiangxi Province Key Laboratory of Oral Diseases & Jiangxi Province Clinical Research Center for Oral Diseases, Nanchang, 330006, China.
Mater Today Bio. 2025 Jul 25;34:102131. doi: 10.1016/j.mtbio.2025.102131. eCollection 2025 Oct.
The immune microenvironment orchestrates bone regeneration, which can be manipulated by macrophage autophagy. Herein, gold nanoparticles with L/D (left-handed or right-handed)-chirality (L/D-AuNPs) were synthesized with chiral glutathione ligands to stereoselectively regulate macrophage autophagy, and further manipulate immune microenvironment for bone regeneration. Notably, L-AuNPs exhibited superior macrophage uptake efficiency and higher autophagy level compared to D-AuNPs. Meanwhile, L-AuNPs improved the osteogenic microenvironment, further promoting bone regeneration. In addition, the results showed that the healing of skull defect was significantly enhanced by L-AuNPs. These findings demonstrated that chiral AuNPs can stereoselectively regulate macrophage autophagy and open an avenue for applications of chiral nanoparticles in osteoimmunity.
免疫微环境协调骨再生，而巨噬细胞自噬可对其进行调控。在此，使用手性谷胱甘肽配体合成了具有L/D（左旋或右旋）手性的金纳米颗粒（L/D-AuNPs），以立体选择性地调节巨噬细胞自噬，并进一步调控免疫微环境促进骨再生。值得注意的是，与D-AuNPs相比，L-AuNPs表现出更高的巨噬细胞摄取效率和更高的自噬水平。同时，L-AuNPs改善了成骨微环境，进一步促进了骨再生。此外，结果表明L-AuNPs显著增强了颅骨缺损的愈合。这些发现表明，手性金纳米颗粒可以立体选择性地调节巨噬细胞自噬，并为手性纳米颗粒在骨免疫中的应用开辟了一条途径。
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