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双膦酸盐诱导的非典型股骨骨折病例中预防性钉固定后的骨折发生——1例罕见病例报告

Fracture Occurrence following Prophylactic Nailing in a Case of Bisphosphonate-induced Atypical Femoral Fracture - A Rare Case Report.

作者信息

Rajamanya Kumardev Arvind, Nayak Tushar, Shah Rahul

机构信息

Department of Orthopaedics, Aster Whitefield Hospital, Bengaluru, Karnataka, India.

出版信息

J Orthop Case Rep. 2025 Aug;15(8):116-120. doi: 10.13107/jocr.2025.v15.i08.5906.

Abstract

INTRODUCTION

Bisphosphonates are effective in osteoporosis management but have been linked to atypical femoral fractures (AFFs) with prolonged use. The management of incomplete AFF remains controversial, particularly regarding the role of prophylactic fixation.

CASE REPORT

A 67-year-old female on long-term bisphosphonate therapy presented with a left subtrochanteric fracture following a minor fall. Imaging revealed an impending AFF in the contralateral right femur, leading to prophylactic intramedullary nailing. Six weeks postoperatively, she developed a minimally displaced fracture on the right femur, which was managed conservatively due to the minimal displacement of the fracture as a result of prophylactic nailing. She achieved full fracture healing and unaided mobility without additional surgical intervention.

CONCLUSION

Prophylactic intramedullary nailing can effectively mitigate fracture displacement and the need for re-surgery in patients with impending AFF. However, further studies are needed to establish standardized management protocols.

摘要

引言

双膦酸盐在骨质疏松症管理中有效,但长期使用与非典型股骨骨折(AFFs)有关。不完全AFF的管理仍存在争议,特别是在预防性固定的作用方面。

病例报告

一名长期接受双膦酸盐治疗的67岁女性在轻微跌倒后出现左转子下骨折。影像学检查显示对侧右股骨有即将发生的AFF,遂进行预防性髓内钉固定。术后六周,她右股骨出现一处轻微移位骨折,由于预防性钉固定导致骨折移位极小,故采取保守治疗。她实现了骨折完全愈合且无需辅助即可活动,无需额外手术干预。

结论

预防性髓内钉固定可有效减轻即将发生AFF患者的骨折移位和再次手术的需求。然而,需要进一步研究以建立标准化管理方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/132d/12328984/c755161ab8ca/JOCR-15-116-g001.jpg

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