Cooper E R, Berner B
J Pharm Sci. 1985 Oct;74(10):1100-2. doi: 10.1002/jps.2600741018.
A model for estimating in vivo skin permeability coefficients for finite doses is presented. The ratio of the maximum value of the excretion rate to the steady-state flux is a function of the thickness of the applied vehicle and the vehicle-skin partition coefficient. The decay rate of the excretion is a function of skin-vehicle parameters for large doses and, under certain conditions, can even reduce to the total excretory rate constant as the dose is decreased.
提出了一种用于估计有限剂量下体内皮肤渗透系数的模型。排泄率最大值与稳态通量的比值是所用载体厚度和载体 - 皮肤分配系数的函数。对于大剂量，排泄的衰减率是皮肤 - 载体参数的函数，并且在某些条件下，随着剂量降低，甚至可以简化为总排泄率常数。
