Rubayiza Paul, Mukisa Robert
School of Pharmacy, Department of Pharmaceutical Chemistry & Analysis, Kampala International University-Western Campus, Bushenyi, Uganda.
J Exp Pharmacol. 2025 Aug 4;17:519-526. doi: 10.2147/JEP.S527972. eCollection 2025.
is a leading cause of respiratory infections, including pneumonia, meningitis, and otitis media. The rise in antimicrobial resistance has complicated treatment strategies, highlighting the need for alternative therapies. Plant-based remedies are increasingly being explored for their antibacterial potential, particularly in traditional medicine.
This study evaluated the antibacterial activity of ethanolic extracts from bark and leaves, individually and in combination, against . The agar well diffusion method was employed to assess zones of inhibition. A combination effect was analyzed by calculating the increase in fold area of inhibition.
Both individual extracts demonstrated antibacterial activity. However, the combination of the two extracts produced larger zones of inhibition than either extract alone. The calculated increase in fold area of inhibition was 0.659, suggesting a synergistic effect.
The combination of and extracts shows enhanced antibacterial efficacy against , supporting their traditional use in managing respiratory infections. Further research is needed to determine the mechanism of action, in vivo efficacy, and safety profile before clinical application.
是包括肺炎、脑膜炎和中耳炎在内的呼吸道感染的主要病因。抗菌药物耐药性的增加使治疗策略变得复杂，凸显了替代疗法的必要性。基于植物的疗法因其抗菌潜力，尤其是在传统医学中，正越来越多地被探索。
本研究评估了树皮和树叶乙醇提取物单独及联合使用对的抗菌活性。采用琼脂扩散法评估抑菌圈。通过计算抑菌面积的增加倍数来分析联合效应。
两种单独的提取物均表现出抗菌活性。然而，两种提取物的联合使用产生的抑菌圈比单独使用任何一种提取物都大。计算得出的抑菌面积增加倍数为0.659，表明存在协同效应。
提取物与提取物的组合对显示出增强的抗菌效果，支持它们在治疗呼吸道感染方面的传统用途。在临床应用之前，需要进一步研究以确定其作用机制、体内疗效和安全性。
