水烟吸食者的心力衰竭:关于心室功能障碍、氧化应激和炎症途径的证据综述
Heart failure in water pipe smokers: a review of evidence on ventricular dysfunction, oxidative stress, and inflammatory pathways.
作者信息
Nzeako Tochukwu R, Elendu Chukwuka, Moradi Ali, Olanisa Olawale, Nwaedozie Somto, Ilonze Onyedika
机构信息
Christiana Care Hospital, Newark, Delaware, USA.
Federal University Teaching Hospital, Owerri, Nigeria.
出版信息
Ann Med Surg (Lond). 2025 Jun 16;87(8):5029-5045. doi: 10.1097/MS9.0000000000003497. eCollection 2025 Aug.
Water pipe smoking, commonly referred to as hookah or shisha, is a centuries-old practice that has gained global popularity in recent decades, particularly among young adults. This resurgence is fueled by its cultural appeal, social nature, and the perception of it being a safer alternative to cigarette smoking. However, mounting evidence suggests that waterpipe smoking has significant cardiovascular consequences, including the development of ventricular dysfunction, a precursor to heart failure. Heart failure (HF), a complex clinical syndrome characterized by the heart's inability to pump blood adequately, affects approximately 64 million people worldwide, with regional variations in prevalence and etiology. In high-income countries, the prevalence ranges from 1-2% of the adult population, increasing to over 10% in individuals above 70 years, while in low- and middle-income countries (LMICs), the prevalence is often underreported due to limited healthcare access. Emerging evidence links water pipe smoking to ventricular dysfunction through mechanisms such as oxidative stress, systemic inflammation, and direct myocardial toxicity. Comparative studies highlight that a single water pipe session delivers greater quantities of carbon monoxide and nicotine than a cigarette, intensifying cardiovascular strain. These substances induce myocardial hypoxia, lipid peroxidation, and cytokine-mediated inflammation, impairing ventricular function. Given the growing prevalence of water pipe smoking, especially among younger populations, this practice constitutes an underrecognized but significant public health risk. Addressing the cardiovascular implications of water pipe smoking requires targeted research and global efforts to enhance awareness, implement preventive strategies, and inform healthcare policies. Water pipe smoking, commonly known as shisha or hookah, is often perceived as a safer alternative to cigarettes. However, mounting evidence shows that it significantly harms the heart. This review highlights how water pipe smoking contributes to heart failure by damaging the heart's pumping ability, increasing oxidative stress, and triggering harmful inflammation. These effects, when prolonged, can lead to severe cardiovascular complications. Understanding these risks is crucial for public awareness and emphasizes the need for stricter regulations and preventive measures against waterpipe smoking.
水烟吸食,通常被称为水烟袋或水烟筒,是一种有着数百年历史的行为,在近几十年里在全球范围内受到欢迎,尤其是在年轻人中。这种复兴得益于其文化吸引力、社交性质以及被认为是比吸烟更安全的选择。然而,越来越多的证据表明,水烟吸食会产生重大的心血管后果,包括心室功能障碍的发展,这是心力衰竭的前兆。心力衰竭(HF)是一种复杂的临床综合征,其特征是心脏无法充分泵血,全球约有6400万人受其影响,患病率和病因存在地区差异。在高收入国家,患病率在成年人口中为1%-2%,在70岁以上人群中增至10%以上,而在低收入和中等收入国家(LMICs),由于医疗服务有限,患病率往往报告不足。新出现的证据通过氧化应激、全身炎症和直接心肌毒性等机制将水烟吸食与心室功能障碍联系起来。比较研究强调,单次水烟吸食比香烟释放更多的一氧化碳和尼古丁,加剧心血管负担。这些物质会导致心肌缺氧、脂质过氧化和细胞因子介导的炎症,损害心室功能。鉴于水烟吸食的流行率不断上升,尤其是在年轻人群中,这种行为构成了一种未得到充分认识但重大的公共卫生风险。应对水烟吸食对心血管的影响需要有针对性的研究和全球努力,以提高认识、实施预防策略并为医疗政策提供信息。水烟吸食,通常被称为水烟筒或水烟袋,通常被认为是比香烟更安全的选择。然而,越来越多的证据表明,它会对心脏造成严重损害。这篇综述强调了水烟吸食如何通过损害心脏的泵血能力、增加氧化应激和引发有害炎症来导致心力衰竭。这些影响如果持续下去,可能会导致严重的心血管并发症。了解这些风险对于公众意识至关重要,并强调需要对水烟吸食实施更严格的监管和预防措施。
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