Risal Ujjwol Prasad
Department of Internal Medicine, B. P. Koirala Institute of Health Sciences, Dharan, Nepal.
Ann Med Surg (Lond). 2025 Jul 16;87(8):5326-5329. doi: 10.1097/MS9.0000000000003595. eCollection 2025 Aug.
Dermatomyositis (DM) is an inflammatory myopathy with a known association with malignancies. The spectrum of associated cancers varies by age and geography, commonly including ovarian, lung, and breast cancers. However, its link with gestational trophoblastic neoplasia (GTN) has not been previously reported.
A 45-year-old woman with recently treated GTN presented with proximal muscle weakness, a facial rash, and elevated muscle enzymes. She was diagnosed clinically with DM and responded well to corticosteroids and methotrexate.
DM can occur before, during, or after cancer diagnosis. This rare case of DM following GTN supports the theory of immune cross-reactivity between tumor and muscle antigens. Diagnosis may rely on clinical criteria in resource-limited settings.
In patients with cancer who present with cutaneous manifestations and muscle symptoms, DM should be considered, irrespective of the cancer type or treatment status.
皮肌炎（DM）是一种炎性肌病，已知与恶性肿瘤有关。相关癌症的范围因年龄和地域而异，通常包括卵巢癌、肺癌和乳腺癌。然而，其与妊娠滋养细胞肿瘤（GTN）的联系此前尚未见报道。
一名45岁近期接受过GTN治疗的女性出现近端肌无力、面部皮疹和肌肉酶升高。临床诊断为DM，对皮质类固醇和甲氨蝶呤反应良好。
DM可在癌症诊断之前、期间或之后发生。这例GTN后发生DM的罕见病例支持肿瘤与肌肉抗原之间免疫交叉反应的理论。在资源有限的情况下，诊断可能依赖临床标准。
对于出现皮肤表现和肌肉症状的癌症患者，无论癌症类型或治疗状态如何，均应考虑DM。
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