基于两样本孟德尔随机化探索白细胞端粒长度与前列腺炎、睾丸炎和附睾炎之间的因果关系
[Exploring the causal relationship between leukocyte telomere length and prostatitis, orchitis, and epididymitis based on a two-sample Mendelian randomization].
作者信息
Li Dan-Yang, Yu Shun, Yang Bo-Hui, Zhang Jun-Bao, Yin Guo-Chen, Wu Lin-Na, Dong Qin-Zuo, Xu Jin-Long, Ning Shu-Ping, Zhao Rong
机构信息
Second School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, China.
First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, China.
出版信息
Zhonghua Nan Ke Xue. 2025 Apr;31(4):306-312.
OBJECTIVE
To investigate the genetic causal relationship of leukocyte telomere length (LTL) with prostatitis, orchitis and epididymitis by two-sample Mendelian randomization (MR).
METHODS
Using LTL as the exposure factor and prostatitis, orchitis and epididymitis as outcome factors, we mined the Database of Genome-Wide Association Studies (GWAS). Then, we analyzed the causal relationship of LTL with prostatitis, orchitis and epididymitis by Mendelian randomization using inverse variance weighting (IVW) as the main method and weighted median and MR-Egger regression as auxiliary methods, determined the horizontal multiplicity by MR-Egger intercept test, and conducted sensitivity analysis using the leaving-one-out method.
RESULTS
A total of 121 related single nucleotide polymorphisms (SNPs) were identified in this study. IVW showed LTL to be a risk factor for prostatitis (OR = 1.383, 95% CI: 1.044－1.832, P = 0.024), and for orchitis and epididymitis as well (OR = 1.770, 95% CI: 1.275－2.456, P = 0.000 6).
CONCLUSION
Genetic evidence from Mendelian randomized analysis indicates that shortening of LTL reduces the risk of prostatitis, orchitis and epididymitis.
目的
通过两样本孟德尔随机化（MR）研究白细胞端粒长度（LTL）与前列腺炎、睾丸炎和附睾炎之间的遗传因果关系。
方法
以LTL作为暴露因素，前列腺炎、睾丸炎和附睾炎作为结局因素，挖掘全基因组关联研究（GWAS）数据库。然后，采用以逆方差加权（IVW）为主、加权中位数和MR-Egger回归为辅助的孟德尔随机化方法分析LTL与前列腺炎、睾丸炎和附睾炎的因果关系，通过MR-Egger截距检验确定水平多重性，并采用留一法进行敏感性分析。
结果
本研究共鉴定出121个相关单核苷酸多态性（SNP）。IVW分析显示，LTL是前列腺炎的危险因素（OR = 1.383，95%CI：1.044－1.832，P = 0.024），也是睾丸炎和附睾炎的危险因素（OR = 1.770，95%CI：1.275－2.456，P = 0.000 6）。
结论
孟德尔随机化分析的遗传证据表明，LTL缩短可降低前列腺炎、睾丸炎和附睾炎的发病风险。
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