Takahashi Satsuki, Matsumura Tomoaki, Sonoda Michiko, Kaneko Tatsuya, Horio Ryosuke, Goto Chihiro, Kurosugi Akane, Ishikawa Tsubasa, Ohta Yuki, Taida Takashi, Nakamura Masato, Okimoto Kenichiro, Kato Jun
Department of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba City, 260-8670, Japan.
Dig Dis Sci. 2025 Aug 11. doi: 10.1007/s10620-025-09309-z.
The causes of most esophageal motility disorders (EMDs) remain unknown. Recent reports have suggested a potential association between the EMD achalasia and varicella zoster virus (VZV) reactivation. This study aimed to investigate the relationship between various EMDs and VZV infection.
This was cross-sectional study. The participants in this study underwent high-resolution manometry (HRM) at Chiba University Hospital between 2022 and 2024. Saliva and blood samples were collected from all patients. The presence of VZV DNA in the saliva was determined using nested polymerase chain reaction (PCR) and electrophoresis. VZV-immunoglobulin M and immunoglobulin G antibody titers were measured in the blood samples. Based on the HRM results, the patients were divided into an EMD group and a normal group. The results were compared between these groups.
A total of 72 patients were included. Of these, 32 (44.4%) were in the normal group and 40 (55.6%) were in the EMD group, including 22 with esophagogastric junction (EGJ) outflow disorders (achalasia and EGJ outflow obstruction) and 18 with peristalsis disorders (absent contractility, distal esophageal spasm, hypercontractile esophagus, and ineffective esophageal motility). One patient with absent contractility had a concurrent herpes zoster infection, and VZV DNA was detected in this patient's saliva. However, all other patients tested negative for VZV DNA. No significant difference in VZV antibody titers was observed between the two groups.
VZV DNA in the saliva and VZV antibody titers do not appear to be associated with EMDs.
大多数食管动力障碍（EMD）的病因尚不清楚。最近的报告表明，EMD失弛缓症与水痘带状疱疹病毒（VZV）再激活之间可能存在关联。本研究旨在探讨各种EMD与VZV感染之间的关系。
这是一项横断面研究。本研究的参与者于2022年至2024年在千叶大学医院接受了高分辨率测压（HRM）。从所有患者中采集唾液和血液样本。使用巢式聚合酶链反应（PCR）和电泳法测定唾液中VZV DNA的存在情况。在血液样本中测量VZV免疫球蛋白M和免疫球蛋白G抗体滴度。根据HRM结果，将患者分为EMD组和正常组。对两组结果进行比较。
共纳入72例患者。其中，32例（44.4%）为正常组患者，40例（55.6%）为EMD组患者，包括22例食管胃交界（EGJ）流出道障碍（失弛缓症和EGJ流出道梗阻）患者和18例蠕动障碍（无收缩力、食管远端痉挛、食管高收缩性和无效食管动力）患者。1例无收缩力患者并发带状疱疹感染，在该患者的唾液中检测到VZV DNA。然而，所有其他患者的VZV DNA检测均为阴性。两组之间未观察到VZV抗体滴度的显著差异。
唾液中的VZV DNA和VZV抗体滴度似乎与EMD无关。
