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纳米诊疗学的新兴趋势:整合成像与治疗以实现精准医疗。

Emerging trends in NanoTheranostics: Integrating imaging and therapy for precision health care.

作者信息

Fahmy Heba M, Bayoumi Laila, Helal Nada F, Mohamed Naglaa R A, Emarh Yassmin, Ahmed Asmaa M

机构信息

Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt.

Chemistry/Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.

出版信息

Int J Pharm. 2025 Oct 15;683:126057. doi: 10.1016/j.ijpharm.2025.126057. Epub 2025 Aug 9.

DOI:10.1016/j.ijpharm.2025.126057
PMID:40789470
Abstract

Nanotheranostics has garnered significant interest for its capacity to improve customized healthcare via targeted and efficient treatment alternatives. Nanotheranostics promises an innovative approach to precision medicine by integrating therapeutic and diagnostic capabilities into nanoscale devices. Nanotheranostics provides an integrated approach that improves diagnosis and facilitates real-time, tailored treatment, revolutionizing patient care. Through the application of nanotheranostic devices, outcomes can be modified for patients on an individualized therapeutic level by taking into consideration individual differences in disease manifestation as well as treatment response. In this review, no aspect of imaging in nanotheranostics is excluded, thus including MRI and CT as well as PET and OI, which are essential for comprehensive analysis needed in medical decision making. Integration of AI and ML into theranostics facilitates predicting treatment outcomes and personalizing the approaches to the methods, which significantly enhances reproducibility in medicine. In addition, several nanoparticles such as lipid-based and polymeric particles, iron oxide, quantum dots, and mesoporous silica have shown promise in diagnosis and targeted drug delivery. These nanoparticles are capable of treating multiple diseases such as cancers, some other neurological disorders, and infectious diseases. While having potential, the field of nanotheranostics still encounters issues regarding clinical applicability, alongside some regulatory hurdles pertaining to new therapeutic agents. Advanced research in this sphere is bound to enhance existing perspectives and fundamentally aid the integration of nanomedicine into conventional health procedures, especially relating to efficacy and the growing emphasis on safe, personalized healthcare.

摘要

纳米诊疗学因其能够通过靶向和高效的治疗方案改善个性化医疗保健而备受关注。纳米诊疗学通过将治疗和诊断功能整合到纳米级设备中,为精准医学提供了一种创新方法。纳米诊疗学提供了一种综合方法,可改善诊断并促进实时、个性化治疗,彻底改变患者护理方式。通过应用纳米诊疗设备,可以根据疾病表现和治疗反应的个体差异,在个体治疗层面上为患者调整治疗结果。在本综述中,纳米诊疗学的成像的各个方面均未被排除,因此包括MRI、CT以及PET和OI,这些对于医疗决策所需的综合分析至关重要。将人工智能和机器学习整合到诊疗学中有助于预测治疗结果并使方法个性化,这显著提高了医学的可重复性。此外,几种纳米颗粒,如脂质基颗粒和聚合物颗粒、氧化铁、量子点和介孔二氧化硅,在诊断和靶向药物递送方面已显示出前景。这些纳米颗粒能够治疗多种疾病,如癌症、其他一些神经系统疾病和传染病。尽管纳米诊疗学领域具有潜力,但仍面临临床适用性问题以及与新型治疗剂相关的一些监管障碍。该领域的前沿研究必将拓展现有视野,并从根本上有助于将纳米医学整合到传统医疗程序中,特别是在疗效以及对安全、个性化医疗保健日益重视方面。

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