Slivar Isabela de Sousa, Zanesco Bruno de Andrade, Martins Manoela Domingues, Matos Leandro Luongo, Nunes Fábio Daumas, Schuch Lauren Frenzel, Wagner Vivian Petersen
Department of Dentistry, School of Dentistry, Universidade de São Paulo (FOUSP), São Paulo, Brazil.
Department of Oral Diagnosis, Piracicaba Dental School, Universidade Estadual de Campinas, Piracicaba (UNICAMP), São Paulo, Brazil.
J Oral Pathol Med. 2025 Sep;54(8):647-657. doi: 10.1111/jop.70028. Epub 2025 Aug 11.
Most studies suggest that NOTCH1 alterations are associated with prognosis in adenoid cystic carcinoma (ACC), but findings remain fragmented. We conducted an integrative analysis to evaluate the prognostic value of NOTCH1-related biomarkers in ACC.
A comprehensive search was conducted across multiple databases. Inclusion criteria comprised studies examining NOTCH1-related features at ACC diagnosis and their relation with survival outcomes. Meta-analysis was performed on studies sharing similar methodology.
Twelve studies met the eligibility criteria. NOTCH1 mutational status, Notch1 immunoexpression, and NICD1 immunoexpression were associated either with overall, disease-free or progression-free survival. Methodological disparities hindered integration of results. Meta-analyses of HRs were conducted with 2 studies for each index factor, revealing a 2.31-fold increased risk of death for primary ACC cases with NOTCH1 mutations, a 2.6-fold increased risk of death for those exhibiting positive NICD1 expression and a 1.91-fold heightened risk of disease recurrence for cases with high Notch1 expression.
This comprehensive review underscores the prognostic relevance of NOTCH1 in ACC, indicating its potential as a valuable risk stratification tool.
大多数研究表明，NOTCH1改变与腺样囊性癌（ACC）的预后相关，但研究结果仍然零散。我们进行了一项综合分析，以评估NOTCH1相关生物标志物在ACC中的预后价值。
在多个数据库中进行了全面检索。纳入标准包括在ACC诊断时检查NOTCH1相关特征及其与生存结果关系的研究。对采用相似方法的研究进行荟萃分析。
12项研究符合纳入标准。NOTCH1突变状态、Notch1免疫表达和NICD1免疫表达与总生存期、无病生存期或无进展生存期相关。方法学差异阻碍了结果的整合。对每个指标因素的2项研究进行了HR的荟萃分析，结果显示NOTCH1突变的原发性ACC病例死亡风险增加2.31倍，NICD1表达阳性者死亡风险增加2.6倍，Notch1高表达病例疾病复发风险增加1.91倍。
这项全面综述强调了NOTCH1在ACC中的预后相关性，表明其作为一种有价值的风险分层工具的潜力。
