García-Rodríguez Víctor, Iglesias-Sancho Maribel, Martin-Poch Albert, Fernández-Figueras Maria Teresa, Salleras-Redonnet Montserrat
Dermatology Department, Hospital Universitari Sagrat Cor, Grupo Hospitalario Quirónsalud, Barcelona, Spain.
Pathology Department, Hospital Universitari General de Catalunya, Grupo Hospitalario Quirónsalud, Sant Cugat del Vallés, Barcelona, Spain.
Dermatol Pract Concept. 2025 Jul 31;15(3):5083. doi: 10.5826/dpc.1503a5083.
RIME is an emerging dermatologic condition marked by prominent mucositis with minimal skin involvement, often mimicking Stevens-Johnson syndrome. While initially linked to Mycoplasma pneumoniae, a broader range of infectious triggers is now recognized.
We present a narrative review of this entity. A proposed diagnostic and therapeutic algorithm is also provided to aid clinicians in clinical practice.
We performed a narrative review of English-language literature on RIME and MIRM indexed in PubMed through 2024, supplemented by clinical insights from the experience of our centre.
Evidence regarding treatment is lacking, with systemic steroids and/or cyclosporine A showing the most benefit. RIME usually portends a good prognosis, with recovery within seven to 21 days, although complications can occur. Recurrences are rare, and subsequent episodes can be triggered by different microorganisms.
RIME represents a distinct clinical entity with a broadening range of infectious triggers beyond Mycoplasma pneumoniae. Prompt recognition, accurate differentiation from mimickers, and a structured diagnostic and therapeutic approach are essential for effective management and improved patient outcomes.
反应性感染性黏膜皮肤疹（RIME）是一种新兴的皮肤病，其特征为显著的黏膜炎，皮肤受累较轻，常类似史蒂文斯-约翰逊综合征。虽然最初与肺炎支原体有关，但现在已认识到更广泛的感染诱因。
我们对该疾病进行叙述性综述。还提供了一种建议的诊断和治疗算法，以帮助临床医生在临床实践中应用。
我们对截至2024年在PubMed中索引的关于RIME和重症感染性反应性黏膜病（MIRM）的英文文献进行了叙述性综述，并辅以我们中心经验的临床见解。
缺乏关于治疗的证据，全身用类固醇和/或环孢素A显示出最大益处。RIME通常预后良好，7至21天内可恢复，尽管可能发生并发症。复发很少见，后续发作可能由不同微生物触发。
RIME代表一种独特的临床实体，其感染诱因范围超出肺炎支原体且不断扩大。及时识别、与类似疾病准确鉴别以及结构化的诊断和治疗方法对于有效管理和改善患者预后至关重要。
