Aksu Aslı, Demir Ayşenur, Günay Hatice, Cetinkaya Pinar Ozdemir, Kurt Birgul Ozkesici, Kaya Hazel Ezgi, Altunay İlknur Kıvanç, Altınel Deniz
University of Health Sciences, Şişli Hamidiye Etfal Training and Research Hospital, Department of Dermatology, İstanbul, Turkey.
University of Health Sciences, Şişli Hamidiye Etfal Training and Research Hospital, Department of Pathology, İstanbul, Turkey.
Dermatol Pract Concept. 2025 Jul 31;15(3):5264. doi: 10.5826/dpc.1503a5264.
The full range of cutaneous comorbidities associated with keratinocyte skin cancers remains to be elucidated.
We aimed to examine other skin diseases in patients with keratinocyte cancer (KC) and to reveal potential associations between them.
Included in the study were 200 patients with KC and 200 disease-free controls. To identify any additional concomitant dermatological conditions, all study groups underwent examination by two dermatologists.
In patients with KC, 87.5% were diagnosed with basal cell carcinoma and 13.5% were diagnosed with squamous cell carcinoma. There was no statistically significant difference between the two groups regarding sunscreen use habits (P =0.284). Patients with KC exhibited a significantly elevated odds ratio (OR) for the presence of rosacea (OR 5.13, 95% CI: 3.2-8.3, P=0.000) and especially erythematotelangiectatic rosacea (ETR) subtype (OR 5.03, 95% CI: 3.1-8.2, P=0.000). An Receiver Operating Characteristic (ROC) curve analysis was conducted to assess the efficacy of rosacea in differentiating between the control group and patients with KC. The sensitivity, specificity, negative predictive value, and positive predictive value for rosacea were 45.5%, 86%, 61.2%, and 76.5%, respectively (AUC 0.658, 95% CI: 0.604-0.711, P=0.000), while for ETR it was 44%, 86.5%, 60.7%, and 76.5%, respectively (AUC 0.653, 95% CI: 0.599-0.706, P=0.000). The presence of rosacea demonstrated a significant efficacy in differentiating patients with KC from the control group in all localizations (P< 0.05).
The risk of rosacea in patients with KC, particularly those with the ETR subtype, was found to be significantly elevated, irrespective of age, sex, or localization.
与角质形成细胞皮肤癌相关的一系列皮肤合并症仍有待阐明。
我们旨在研究角质形成细胞癌（KC）患者的其他皮肤疾病，并揭示它们之间的潜在关联。
该研究纳入了200例KC患者和200例无病对照。为了确定任何其他伴随的皮肤病，所有研究组均由两名皮肤科医生进行检查。
在KC患者中，87.5%被诊断为基底细胞癌，13.5%被诊断为鳞状细胞癌。两组在防晒习惯方面无统计学显著差异（P = 0.284）。KC患者酒渣鼻的优势比（OR）显著升高（OR 5.13，95%CI：3.2 - 8.3，P = 0.000），尤其是红斑毛细血管扩张型酒渣鼻（ETR）亚型（OR 5.03，95%CI：3.1 - 8.2，P = 0.000）。进行了受试者工作特征（ROC）曲线分析，以评估酒渣鼻在区分对照组和KC患者方面的效能。酒渣鼻的敏感性、特异性、阴性预测值和阳性预测值分别为45.5%、86%、61.2%和76.5%（AUC 0.658，95%CI：0.604 - 0.711，P = 0.000），而ETR分别为44%、86.5%、60.7%和76.5%（AUC 0.653，95%CI：0.599 - 0.706，P = 0.000）。酒渣鼻的存在在区分所有部位的KC患者与对照组方面显示出显著效能（P < 0.05）。
发现KC患者，尤其是ETR亚型患者患酒渣鼻的风险显著升高，与年龄、性别或部位无关。
