De La Cueva Dobao Pablo, Barredo Laia Curto, Salvador Juan Francisco Silvestre, Serra-Baldrich Esther, Pinto Pedro Herranz, Cano Natalia Hernández, De Frutos Francisco Javier Ortiz, Gullón Gastón Roustan, Belloso Rosa María Lzu, Ortega Irene Arévalo, Quesada Alicia González, Gutiérrez Manuel Galán, Calzada Yolanda Gilaberte, Torredemer Daniel Arumi, Felius Noelia Llevat, Martín Irene Hernández, Laserna Francisco José Rebollo
Hospital Universitario Infanta Leonor, Madrid, Spain.
Hospital del Mar, Ciutat Vella, Barcelona, Spain.
Dermatol Pract Concept. 2025 Jul 31;15(3):5538. doi: 10.5826/dpc.1503a5538.
Atopic dermatitis (AD) is a chronic inflammatory condition associated with a significant physical, psychological, and economic burden. This study aimed to determine the multidimensional impact of AD on patients and the Spanish healthcare system.
The present multicenter descriptive cross-sectional study was conducted at 12 Spanish sites to detect clinical practice assessments and validated patient-reported measures.
A total of 62 patients were included (54.8% males; mean age: 33.1 years). According to the validated Investigator Global Assessment scale for AD, 61.3% and 38.7% of patients had moderate and severe AD, respectively. AD involved a mean of 43.3% body surface area, with patients reporting a median of 4.0 flares in the past year. The mean Patient-Oriented Eczema Measure (POEM) questionnaire score was 19.8, indicating severe eczema. In addition, 57.1% of patients reported daily pain from scratching or skin inflammation. The mean Dermatology Life Quality Index (DLQI) was 14.3, showing a strong AD impact on patients' quality of life, positively correlated with severity, pruritus, and pain. AD also affected work productivity and sleep, with over 50% of patients reporting impairments in daily activities. Treatment patterns showed predominant use of topical corticosteroids (81.5%). Although no patient required hospitalization in the previous year, 25% resorted to alternative therapies/unlicensed products.
AD profoundly impacts patients' quality of life and entails high economic costs. This study emphasizes the need for more effective treatment strategies and an improved understanding of the AD burden to utilize public healthcare resources more efficiently.
特应性皮炎（AD）是一种慢性炎症性疾病，会带来巨大的身体、心理和经济负担。本研究旨在确定AD对患者以及西班牙医疗保健系统的多维度影响。
本项多中心描述性横断面研究在西班牙的12个地点开展，以检测临床实践评估和经过验证的患者报告指标。
共纳入62例患者（男性占54.8%；平均年龄：33.1岁）。根据经过验证的AD研究者整体评估量表，分别有61.3%和38.7%的患者患有中度和重度AD。AD累及的体表面积平均为43.3%，患者报告在过去一年中皮疹发作的中位数为4.0次。以患者为导向的湿疹测量（POEM）问卷平均得分为19.8，表明为重度湿疹。此外，57.1%的患者报告每天因搔抓或皮肤炎症而疼痛。皮肤病生活质量指数（DLQI）平均为14.3，表明AD对患者生活质量有很大影响，与严重程度、瘙痒和疼痛呈正相关。AD还影响工作效率和睡眠，超过50%的患者报告日常活动受到影响。治疗模式显示局部用糖皮质激素的使用最为普遍（81.5%）。尽管前一年没有患者需要住院治疗，但25%的患者采用了替代疗法/未经许可的产品。
AD对患者的生活质量有深远影响，并带来高昂的经济成本。本研究强调需要更有效的治疗策略，以及更好地了解AD负担，以便更有效地利用公共医疗资源。
