Cao Changqing, Mu Jing, Hu Guiying, Wang Yali, Gong Yigu
Department of Pediatrics, The First Hospital of Lanzhou University, 730000 Lanzhou, Gansu, China.
Actas Esp Psiquiatr. 2025 Aug;53(4):902-913. doi: 10.62641/aep.v53i4.1790.
The pathophysiological mechanisms and relevant biological markers for epileptic seizures largely remained unknown. However, several studies have reported elevated levels of inflammatory factors in the serum of individuals with epileptic seizures. Therefore, this study aims to explore the relationship between inflammatory factors and epileptic seizures.
We retrieved relevant literature published in various databases, including Embase, PubMed, Cochrane Library, Web of Science, China Wanfang, HowNet, Chinese Biomedical Literature, and VIP, from inception to December 2023. The relationship between inflammatory factors, such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), and epileptic seizure was assessed. The selected manuscripts were evaluated based on the predetermined inclusion and exclusion criteria, and relevant data were extracted for meta-analysis using Rev Man 5.0 software (RevMan, Oxford, UK) and Stata 12.
We observed that individuals with epileptic seizures had significantly elevated levels of IL-1β (random-effects model, Standardized Mean Difference (SMD) = 1.87, 95% confidence interval (CI) = [1.17, 2.56], I2 = 96.6%, p = 0.010), IL-6 (SMD = 1.73, 95% CI = [0.41, 3.05], I2 = 96.9%, p = 0.010), and TNF-α (random-effects model, SMD = 2.16, 95% CI = [1.13, 3.18], I2 = 96.5%, p = 0.010). Moreover, the subgroup analysis indicated significant differences between the two groups for the country (origin of publication) (SMD = 1.87, 95% CI = [1.17, 2.56], I2 = 96.6%, p < 0.001), sampling time (SMD = 1.87, 95% CI = [1.17, 2.56], I2 = 96.6%, p = 0.010), and sample source (SMD = 1.87, 95% CI = [1.17, 2.56], I2 = 96.6%, p = 0.010).
The IL-1β, IL-6, and TNF-α levels are increased in individuals with epileptic seizures, which could serve as effective biomarkers for epileptogenesis.
癫痫发作的病理生理机制和相关生物标志物在很大程度上仍不清楚。然而，多项研究报告称癫痫发作患者血清中的炎症因子水平升高。因此，本研究旨在探讨炎症因子与癫痫发作之间的关系。
我们检索了从创刊到2023年12月在多个数据库中发表的相关文献，包括Embase、PubMed、Cochrane图书馆、Web of Science、中国万方、知网、中国生物医学文献数据库和维普。评估了炎症因子，如白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）与癫痫发作之间的关系。根据预先确定的纳入和排除标准对所选手稿进行评估，并使用Rev Man 5.0软件（RevMan，英国牛津）和Stata 12提取相关数据进行荟萃分析。
我们观察到癫痫发作患者的IL-1β水平显著升高（随机效应模型，标准化均数差（SMD）=1.87，95%置信区间（CI）=[1.17，2.56]，I²=96.6%，p=0.010），IL-6水平显著升高（SMD=1.73，95%CI=[0.41，3.05]，I²=96.9%，p=0.010），以及TNF-α水平显著升高（随机效应模型，SMD=2.16，95%CI=[1.13，3.18]，I²=96.5%，p=0.010）。此外，亚组分析表明两组在国家（发表来源）（SMD=1.87，95%CI=[1.17，2.56]，I²=96.6%，p<0.001）、采样时间（SMD=1.87，95%CI=[1.17，2.56]，I²=96.6%，p=0.010）和样本来源（SMD=1.87，95%CI=[1.17，2.56]，I²=96.6%，p=0.010）方面存在显著差异。
癫痫发作患者的IL-1β、IL-6和TNF-α水平升高，这可能作为癫痫发生的有效生物标志物。
