Kler Aditya, Dutta Nirjhar, Theis Jake, Guerrero Vinsard Daniela
Division of Hospital Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN.
Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Minnesota, Minneapolis, MN.
ACG Case Rep J. 2025 Aug 11;12(8):e01796. doi: 10.14309/crj.0000000000001796. eCollection 2025 Aug.
IgG-4 related disease (IgG4-RD) is an autoimmune disease that can affect multiple organs and mimic adenocarcinoma of the pancreas. We describe the case of a 74-year-old man who presented with pancreatic mass and biliary obstruction. He was initially diagnosed with pancreatic adenocarcinoma and was started on chemotherapy. Eventually, he was diagnosed with IgG-4 related disease with autoimmune pancreatitis type 1 and IgG-4 sclerosing cholangitis with rapid improvement of symptoms and clinical findings after receiving steroid therapy.
IgG4相关疾病（IgG4-RD）是一种可累及多个器官并酷似胰腺腺癌的自身免疫性疾病。我们描述了一名74岁男性患者的病例，该患者表现为胰腺肿块和胆管梗阻。他最初被诊断为胰腺腺癌并开始接受化疗。最终，他被诊断为1型自身免疫性胰腺炎合并IgG4相关疾病以及IgG4硬化性胆管炎，在接受类固醇治疗后症状和临床检查结果迅速改善。
