Tadasa Edosa, Kemal Eman
School of Medical Laboratory Sciences, Faculty of Health Sciences, Jimma University, Jimma, Oromia, Ethiopia.
Adv Hematol. 2025 Aug 4;2025:2225431. doi: 10.1155/ah/2225431. eCollection 2025.
Diabetes is a significant worldwide health challenge associated with significant metabolic, cellular, and hematological disturbances. Hematological alterations are well-documented complications of diabetes and play a crucial role in the progression of diabetes related pathology. While extensive data exist globally on hematological parameters in type 2 diabetes mellitus (T2DM), specific insights into these parameters and their local determinants within study area remain limited. Therefore, this study aimed to assess the hematological parameters among adult patients diagnosed with T2DM in JUMC at Jimma, Southwest, Ethiopia, 2024. A total of 200 medical charts of adults with T2DM who registered for follow-up at Jimma University Medical Center were reviewed from December 2023 to February 2024. Data were collected using a data extraction checklist. Bivariate and multivariate logistic regression analyses were performed to identify factors associated with hematologic abnormalities. A value less than 0.05 indicates statistical significance. The overall prevalence of anemia and leukocytosis in adults with T2DM was 14.0% and 12.0%, respectively. Neutrophilia was the common white blood cell (WBC) abnormality detected in 9.5% of the patients. Besides, thrombocytopenia and thrombocytosis were observed in 2.5% and 1.5% of the patients, respectively. Increasing age 5.28 (95% CI: 1.07-26.1) and duration of diabetes mellitus (≥ 3 years) (AOD = 3.1 (95% CI: 1.02-9.5)) were significantly associated with anemia and leukocytosis, respectively. This study found a prevalence of hematological abnormalities in adults with T2DM, including anemia, elevated WBC count, increased neutrophils, and thrombocytopenia. Anemia was associated with advanced age, while leukocytosis was associated with a longer diabetes duration. Therefore, it is recommended to start regularly screening T2DM patients for hematological abnormalities to improve clinical practice, guide treatment decisions, and develop targeted interventions.
糖尿病是一项重大的全球性健康挑战，与显著的代谢、细胞和血液学紊乱相关。血液学改变是糖尿病的充分记录的并发症，并且在糖尿病相关病理进展中起关键作用。虽然全球存在关于2型糖尿病（T2DM）血液学参数的大量数据，但对这些参数及其在研究区域内的局部决定因素的具体见解仍然有限。因此，本研究旨在评估2024年在埃塞俄比亚西南部吉马的JUMC诊断为T2DM的成年患者的血液学参数。从2023年12月至2024年2月，对在吉马大学医学中心登记进行随访的200例成年T2DM患者的病历进行了回顾。使用数据提取清单收集数据。进行双变量和多变量逻辑回归分析以确定与血液学异常相关的因素。P值小于0.05表示具有统计学意义。T2DM成年患者中贫血和白细胞增多的总体患病率分别为14.0%和12.0%。中性粒细胞增多是在9.5%的患者中检测到的常见白细胞（WBC）异常。此外，分别在2.5%和1.5%的患者中观察到血小板减少和血小板增多。年龄增加5.28（95%CI：1.07 - 26.1）和糖尿病病程（≥3年）（优势比 = 3.1（95%CI：1.02 - 9.5））分别与贫血和白细胞增多显著相关。本研究发现T2DM成年患者中存在血液学异常，包括贫血、白细胞计数升高、中性粒细胞增加和血小板减少。贫血与高龄相关，而白细胞增多与较长的糖尿病病程相关。因此，建议开始定期对T2DM患者进行血液学异常筛查，以改善临床实践、指导治疗决策并制定针对性干预措施。
