Frings Lars, Hellwig Sabine, Brumberg Joachim, Rau Alexander, Mix Michael, Blazhenets Ganna, Urbach Horst, Meyer Philipp T
Department of Nuclear Medicine Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg Freiburg Germany.
Department of Psychiatry and Psychotherapy Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg Freiburg Germany.
Alzheimers Dement (Amst). 2025 Aug 11;17(3):e70142. doi: 10.1002/dad2.70142. eCollection 2025 Jul-Sep.
We investigated whether age of patients with Alzheimer's disease (AD) at first visit to a memory clinic predicts biomarker findings along the amyloid beta deposition, pathologic tau, and neurodegeneration (ATN) scheme and moderates the association between ATN biomarkers and cognition.
We evaluated [C]Pittsburgh compound B positron emission tomography (PET), florzolotau (F) PET, [F]fluorodeoxyglucose PET, T1-weighted magnetic resonance imaging, and cognitive assessments ( = 190/63/252/687/2198) of a total of 2355 AD patients. We assessed direct and moderating effects of age.
Tau burden and hypometabolism were more severe in younger AD patients. Gray matter volume of the medial temporal lobe (MTL) was reduced to a greater extent in older patients. Relationships between different imaging modalities or between single imaging modalities and cognition were not moderated by age.
In contrast to more severe tau burden and hypometabolism in younger patients, MTL atrophy was more pronounced in older patients. Relationships between markers of pathology and those of neurodegeneration were not associated with age.
Amyloid beta load as a biomarker of pathology burden was not associated with age at first visit to a memory clinic.Tau burden was higher, and glucose metabolism was lower in younger Alzheimer's disease (AD) patients.By contrast, medial temporal lobe atrophy was less severe in younger AD patients.Younger AD patients showed more severe memory deficits with respect to age-appropriate normative data.Age had no moderating effect on relationships between different imaging variables or between single imaging variables and cognition.
我们调查了阿尔茨海默病（AD）患者首次就诊于记忆门诊时的年龄是否能预测沿淀粉样β沉积、病理性tau和神经退行性变（ATN）方案的生物标志物结果，以及年龄是否会调节ATN生物标志物与认知之间的关联。
我们评估了2355例AD患者的[C]匹兹堡化合物B正电子发射断层扫描（PET）、florzolotau（F）PET、[F]氟脱氧葡萄糖PET、T1加权磁共振成像和认知评估（分别为190/63/252/687/2198例）。我们评估了年龄的直接和调节作用。
年轻AD患者的tau负荷和代谢减退更为严重。老年患者内侧颞叶（MTL）的灰质体积减少更为明显。不同成像方式之间或单一成像方式与认知之间的关系不受年龄调节。
与年轻患者更严重的tau负荷和代谢减退相反，老年患者的MTL萎缩更为明显。病理学标志物与神经退行性变标志物之间的关系与年龄无关。
作为病理学负担生物标志物的淀粉样β负荷与首次就诊于记忆门诊时的年龄无关。年轻的阿尔茨海默病（AD）患者tau负荷更高，葡萄糖代谢更低。相比之下，年轻AD患者的内侧颞叶萎缩较轻。相对于适合年龄的正常数据，年轻AD患者表现出更严重的记忆缺陷。年龄对不同成像变量之间或单一成像变量与认知之间的关系没有调节作用。
