NeuroNetwork for Emerging Therapies, University of Michigan, Ann Arbor, MI 48109, USA.
NeuroNetwork for Emerging Therapies, University of Michigan, Ann Arbor, MI 48109, USA; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
J Diabetes Complications. 2022 Nov;36(11):108333. doi: 10.1016/j.jdiacomp.2022.108333. Epub 2022 Oct 5.
The world faces a pandemic-level prevalence of type 2 diabetes. In parallel with this massive burden of metabolic disease is the growing prevalence of dementia as the population ages. The two health issues are intertwined. The Lancet Commission on dementia prevention, intervention, and care was convened to tackle the growing global concern of dementia by identifying risk factors. It concluded, along with other studies, that diabetes as well as obesity and the metabolic syndrome more broadly, which are frequently comorbid, raise the risk of developing dementia. Type 2 diabetes is a modifiable risk factor; however, it is uncertain whether anti-diabetic drugs mitigate risk of developing dementia. Reasons are manifold but constitute a critical knowledge gap in the field. This review outlines studies of type 2 diabetes on risk of dementia, illustrating key concepts. Moreover, it identifies knowledge gaps, reviews strategies to help fill these gaps, and concludes with a series of recommendations to mitigate risk and advance understanding of type 2 diabetes and dementia.
世界正面临着 2 型糖尿病流行的大流行水平。随着人口老龄化，代谢疾病的负担越来越大，痴呆症的发病率也在不断上升。这两个健康问题相互交织。老年痴呆症预防、干预和护理柳叶刀委员会的成立是为了通过识别风险因素来应对全球对痴呆症日益增长的关注。它与其他研究一起得出结论，糖尿病以及肥胖症和更广泛的代谢综合征，这些疾病经常同时存在，会增加患痴呆症的风险。2 型糖尿病是一个可以改变的风险因素；然而，尚不确定抗糖尿病药物是否能降低患痴呆症的风险。原因有很多，但这构成了该领域的一个关键知识空白。这篇综述概述了 2 型糖尿病对痴呆风险的研究，说明了关键概念。此外，它还确定了知识空白，并审查了帮助填补这些空白的策略，最后提出了一系列建议，以降低风险，增进对 2 型糖尿病和痴呆症的理解。
