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《2025年中国阿尔茨海默病报告》

The China Alzheimer Report 2025.

作者信息

Zhi Nan, Ren Rujing, Qi Jinlei, Liu Xinya, Yun Zike, Lin Shaohui, Hu Yisong, Li Haixia, Xie Xinyi, Wang Jintao, Li Jianping, Zhu Yikang, Gao Mengyi, Yang Junjie, Wang Yiran, Jing Yurong, Geng Jieli, Cao Wenwei, Xu Qun, Yu Xiaoping, Zhu Yuan, Zhou Ying, Wang Lin, Gao Chao, Li Binyin, Chen Shengdi, Yuan Fang, Dou Ronghua, Liu Xiaoyun, Li Xuena, Yin Yafu, Chang Yan, Xu Gang, Zhong Yanting, Li Chunbo, Wang Ying, Zhou Maigeng, Wang Gang

机构信息

Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

Gen Psychiatr. 2025 Aug 7;38(4):e102020. doi: 10.1136/gpsych-2024-102020. eCollection 2025.

DOI:10.1136/gpsych-2024-102020
PMID:40792123
原文链接:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12336476/
Abstract

With the sustained growth of the economy and significant changes in social demographics, the issue of elderly-related diseases has increasingly drawn attention, particularly. Alzheimer's disease (AD), as a representative disease of neurodegenerative diseases, has become a major challenge, affecting the health and quality of life of the elderly population severely. In recent years, the incidence, prevalence and mortality rates of AD have increased in China, imposing substantial economic burdens on families, society and the entire healthcare system. To proactively address this challenge and respond to the national 'Healthy China Action' initiative, leading experts from authoritative institutions jointly authored the China Alzheimer Report 2025. Building on previous editions, this report updates epidemiological data on AD in China, thoroughly analyses the latest economic burdens of the disease and comprehensively evaluates the current status of AD diagnosis and treatment services, as well as the allocation of public health resources in our country. Its release reflects China's progress in AD research and prevention, underscores societal concern for elderly health and aims to provide scientific guidance and data support for AD prevention, diagnosis and treatment. It also facilitates academic exchanges and cooperation, enhancing public awareness and promoting active participation in elderly healthcare, towards achieving 'healthy ageing' in China.

摘要

随着经济的持续增长和社会人口结构的显著变化,与老年人相关的疾病问题日益受到关注,尤其是阿尔茨海默病(AD),作为神经退行性疾病的代表性疾病,已成为一项重大挑战,严重影响老年人群的健康和生活质量。近年来,中国AD的发病率、患病率和死亡率均有所上升,给家庭、社会和整个医疗体系带来了沉重的经济负担。为积极应对这一挑战并响应国家“健康中国行动”倡议,权威机构的顶尖专家共同撰写了《中国阿尔茨海默病报告2025》。本报告在以往版本的基础上,更新了中国AD的流行病学数据,深入分析了该疾病最新的经济负担,并全面评估了我国AD诊断和治疗服务的现状以及公共卫生资源的配置情况。其发布反映了中国在AD研究与预防方面的进展,凸显了社会对老年人健康的关注,旨在为AD的预防、诊断和治疗提供科学指导与数据支持。它还促进了学术交流与合作,提高公众意识并推动积极参与老年保健,以实现中国的“健康老龄化”。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c19/12336476/08bc6587243b/gpsych-38-4-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c19/12336476/025267c00207/gpsych-38-4-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c19/12336476/08bc6587243b/gpsych-38-4-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c19/12336476/025267c00207/gpsych-38-4-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c19/12336476/08bc6587243b/gpsych-38-4-g003.jpg

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本文引用的文献

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Promising outcomes 5 weeks after a surgical cervical shunting procedure to unclog cerebral lymphatic systems in a patient with Alzheimer's disease.在一名阿尔茨海默病患者身上进行手术性颈部分流手术以疏通脑淋巴系统5周后出现了有希望的结果。
Gen Psychiatr. 2024 Jun 22;37(3):e101641. doi: 10.1136/gpsych-2024-101641. eCollection 2024.
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Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup.修订的阿尔茨海默病诊断和分期标准:阿尔茨海默病协会工作组。
Alzheimers Dement. 2024 Aug;20(8):5143-5169. doi: 10.1002/alz.13859. Epub 2024 Jun 27.
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Burden of disease scenarios for 204 countries and territories, 2022-2050: a forecasting analysis for the Global Burden of Disease Study 2021.
204 个国家和地区 2022-2050 年疾病负担情景:2021 年全球疾病负担研究的预测分析。
Lancet. 2024 May 18;403(10440):2204-2256. doi: 10.1016/S0140-6736(24)00685-8.
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2024 Alzheimer's disease facts and figures.2024 年阿尔茨海默病事实和数据。
Alzheimers Dement. 2024 May;20(5):3708-3821. doi: 10.1002/alz.13809. Epub 2024 Apr 30.
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Biomarker Changes during 20 Years Preceding Alzheimer's Disease.阿尔茨海默病发病前 20 年的生物标志物变化。
N Engl J Med. 2024 Feb 22;390(8):712-722. doi: 10.1056/NEJMoa2310168.
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Profiles of subgingival microbiomes and gingival crevicular metabolic signatures in patients with amnestic mild cognitive impairment and Alzheimer's disease.遗忘型轻度认知障碍和阿尔茨海默病患者龈下微生物群和龈沟代谢特征
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Specific serum autoantibodies predict the development and progression of Alzheimer's disease with high accuracy.特定的血清自身抗体能够高度准确地预测阿尔茨海默病的发生和发展。
Brain Behav Immun. 2024 Jan;115:543-554. doi: 10.1016/j.bbi.2023.11.018. Epub 2023 Nov 19.
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