心脏磁共振成像评估特发性室性心律失常患者二尖瓣环分离的患病率、特征及致心律失常基质
Prevalence, Characteristics, and Arrhythmogenic Substrate of Mitral Annular Disjunction Assessed by Cardiac Magnetic Resonance Imaging in Patients With Apparently Idiopathic Ventricular Arrhythmia.
作者信息
Asada Saori, Morita Hiroshi, Toh Norihisa, Masuda Takuro, Ueoka Akira, Miyamoto Masakazu, Nakagawa Koji, Nishii Nobuhiro, Nakamura Kazufumi, Yuasa Shinsuke
机构信息
Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences Okayama University Graduate School of Medicine and Dentistry Okayama Japan.
Department of Cardiovascular Therapeutics Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.
出版信息
J Arrhythm. 2025 Aug 10;41(4):e70172. doi: 10.1002/joa3.70172. eCollection 2025 Aug.
BACKGROUND
Mitral annular disjunction (MAD) is linked to an increased risk of sudden cardiac death, but its association with ventricular arrhythmias (VAs) in Japanese patients is unclear.
METHODS
We retrospectively analyzed 129 Japanese patients with VAs and no overt structural heart disease who underwent echocardiography and cardiac MRI.
RESULTS
MAD was diagnosed in 7.0%, and in 14% of patients with VAs originating from the mitral valve apparatus. MAD was significantly associated with multifocal VAs, late gadolinium enhancement in the papillary muscles, and greater mitral regurgitation.
CONCLUSION
MAD may be an important arrhythmogenic substrate in apparently idiopathic VAs among Japanese patients.
背景
二尖瓣环分离（MAD）与心脏性猝死风险增加有关，但在日本患者中其与室性心律失常（VAs）的关联尚不清楚。
方法
我们回顾性分析了129例接受超声心动图和心脏磁共振成像检查、无明显结构性心脏病的日本室性心律失常患者。
结果
7.0%的患者被诊断为二尖瓣环分离，在起源于二尖瓣装置的室性心律失常患者中这一比例为14%。二尖瓣环分离与多灶性室性心律失常、乳头肌延迟钆增强以及更严重的二尖瓣反流显著相关。
结论
在日本患者中，二尖瓣环分离可能是明显特发性室性心律失常的一个重要致心律失常基质。
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