Xie Zehang, Wu Zhenguo, Liu Yan, Gu Yu, Niu Jiahao, Lv Kun
Central Laboratory, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.
Key Laboratory of Non-Coding RNA Transformation Research of Anhui Higher Education Institutes (Wannan Medical College), Wuhu, China.
Front Microbiol. 2025 Jul 28;16:1551515. doi: 10.3389/fmicb.2025.1551515. eCollection 2025.
The human body has a diverse range of microbiota that influences human physiological processes and alters disease risk, involving cancer. Metagenomic sequencing investigations have revealed that the microbiota is an element of the tumor microenvironment, affecting tumor proliferation and responsiveness to current anticancer treatments. The notion of intratumoral microbiota was subsequently introduced. Intratumoral microorganisms have been identified in kinds of cancer, including pancreatic, colorectal, liver, esophageal, breast, and lung malignancies. Microbiota may inhabit tumor tissues by mucosal breakdown, neighboring tissue migration, and hematogenous spread, influencing the biological behavior of tumors as a significant component of tumor's microenvironment. The intratumoral microbiota may facilitate the onset and progression of malignancies through DNA mutations, activation of carcinogenic pathways, alteration of anticancer medication metabolism, and commencement of metastasis. This document is to present an overview of intratumoral microbiota, their prevalence and progression in cancer, their detection and therapy, and to evaluate the potential and limitations of research in this domain. We intend to generate ideas for investigating intratumoral microbiota as possible treatment targets and biomarkers for tumor assessment, prognosis, and detection.
人体拥有各种各样的微生物群，它们影响人体生理过程并改变疾病风险，包括癌症风险。宏基因组测序研究表明，微生物群是肿瘤微环境的一个组成部分，影响肿瘤增殖以及对当前抗癌治疗的反应。随后引入了肿瘤内微生物群的概念。在包括胰腺癌、结直肠癌、肝癌、食管癌、乳腺癌和肺癌等多种癌症中都已发现肿瘤内微生物。微生物群可能通过黏膜破损、邻近组织迁移和血行播散等方式栖息于肿瘤组织中，作为肿瘤微环境的重要组成部分影响肿瘤的生物学行为。肿瘤内微生物群可能通过DNA突变、致癌途径激活、抗癌药物代谢改变以及转移的起始来促进恶性肿瘤的发生和发展。本文旨在概述肿瘤内微生物群、它们在癌症中的发生率和进展情况、它们的检测与治疗方法，并评估该领域研究的潜力和局限性。我们旨在为将肿瘤内微生物群作为肿瘤评估、预后和检测的潜在治疗靶点及生物标志物的研究提供思路。
