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脑干缺血继发先天性角膜麻醉作为新生儿缺氧缺血性脑病的罕见并发症

Congenital Corneal Anesthesia Secondary to Brainstem Ischemia as a Rare Complication of Neonatal Hypoxic-Ischemic Encephalopathy.

作者信息

Frarchi Mohammed, Bouslous Nabil, Laakri Jalal, Ajbar Khaoula, Moustaine Omar

机构信息

Ophthalmology, Souss-Massa University Hospital, Agadir, MAR.

出版信息

Cureus. 2025 Jul 12;17(7):e87777. doi: 10.7759/cureus.87777. eCollection 2025 Jul.

Abstract

We report the case of a very rare instance of congenital corneal anesthesia secondary to brainstem lesions following neonatal hypoxic-ischemic encephalopathy. It's the case of a 7-month-old baby with a history of neonatal asphyxia who presented with spontaneous corneal ulcerations and corneal anesthesia associated with brainstem lesions and brain lesions visible on MRI, secondary to neonatal hypoxic-ischemic encephalopathy. The case of the baby was complicated by the superinfection of the ulceration. He was treated with fortified antibiotics, eyedrops, and frequent instillation of eye lubricants and ointments. The evolution was marked by the healing of the ulceration and the improvement of the corneal sensitivity; however, there were sequelae in the more affected eye by the formation of a corneal pannus.

摘要

我们报告了一例非常罕见的病例,该病例为新生儿缺氧缺血性脑病后继发脑干病变导致的先天性角膜麻醉。这是一名7个月大的婴儿,有新生儿窒息史,出现自发性角膜溃疡和角膜麻醉,同时伴有MRI可见的脑干病变和脑损伤,继发于新生儿缺氧缺血性脑病。该婴儿的病例因溃疡的二重感染而复杂化。他接受了强化抗生素、眼药水治疗,并频繁滴注眼部润滑剂和眼膏。病情演变的特点是溃疡愈合和角膜敏感性改善;然而,受影响更严重的眼睛出现了角膜血管翳形成的后遗症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d996/12338002/bfbe5db601e3/cureus-0017-00000087777-i01.jpg

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