[Immunologic diagnosis of intravascular blood clotting and intravascular thrombus formation among patients with ischemic heart disease].

Rabbit plasmas immune to fibrinogen/fibrin and thrombin, with antibody titres of 1:1024, were obtained by rabbit immunization with fibrinogen and thrombin. Immunologic methods were shown to be capable of detecting thrombinemia and increased fibrinogen/fibrin levels, as well as reduced titres of anti-thrombin and anti-fibrinogen/fibrin antibodies, i. e. the presence of intravascular coagulation and thrombogenesis in the circulating blood. These changes are particularly pronounced in coronary patients during the first days of acute myocardial infarction and in those with thromboembolic complications of varying localization. Patients with unstable angina also show reduced titres of antithrombin and antifibrinogen/fibrin antibodies, as compared to clinically normal subjects; yet the reduction here is less marked than the one observed during the first days of acute myocardial infarction.