Lomi Neiwete, Das Deepsekhar, Chawla Bhavna, Ghosh Tapashree, Rajasekaran Dhanabalan, Tandon Radhika
Ophthalmology, All India Institute of Medical Sciences, New Delhi, New Delhi, IND.
Medical Physics, All India Institute of Medical Sciences, New Delhi, New Delhi, IND.
Cureus. 2025 Jul 11;17(7):e87727. doi: 10.7759/cureus.87727. eCollection 2025 Jul.
Anterior segment tumors pose challenges in treatment due to their location and potential for globe loss. Plaque brachytherapy allows globe salvage, but placing plaques over the cornea and limbus may lead to epithelial defects and ulcers. We report a novel technique using a bandage contact lens as a buffer between the plaque and cornea in a 48-year-old woman with iridociliary melanoma. The lens thickness (0.07 mm) was included in radiation dose planning. The patient had no corneal complications and showed tumor regression at seven months. Two additional patients treated similarly showed stable tumors and no adverse effects at six months. This method may offer a safer alternative to amniotic membrane grafts for anterior segment brachytherapy, reducing corneal toxicity without compromising tumor control.
前段肿瘤因其位置及眼球丧失的可能性，在治疗上颇具挑战。敷贴近距离放射治疗可挽救眼球，但将敷贴置于角膜和角膜缘上方可能导致上皮缺损和溃疡。我们报告了一种新技术，在一名48岁患有虹膜睫状体黑色素瘤的女性患者中，使用绷带式隐形眼镜作为敷贴与角膜之间的缓冲物。镜片厚度（0.07毫米）被纳入放射剂量规划。该患者未出现角膜并发症，且在七个月时显示肿瘤消退。另外两名接受类似治疗的患者在六个月时肿瘤稳定，未出现不良反应。对于前段近距离放射治疗，这种方法可能为羊膜移植提供一种更安全的替代方案，在不影响肿瘤控制的情况下降低角膜毒性。
