饮食矿物质摄入量与类风湿性关节炎之间的关联：来自英国生物银行和美国国家健康与营养检查调查的证据。

Associations between dietary mineral intake and rheumatoid arthritis: evidence from UK biobank and NHANES.

作者信息

Hui Jingni, Yang Xuena, Kang Meijuan, He Dan, Gou Yifan, Zhou Ruixue, Liu Chen, Liu Ye, Wang Bingyi, Shi Panxing, Cheng Shiqiang, Pan Chuyu, Zhao Boyue, Feng Jin, Wei Wenming, Jia Yumeng, Zhang Feng

机构信息

Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.

出版信息

Rheumatology (Oxford). 2025 Aug 8. doi: 10.1093/rheumatology/keaf395.

DOI:10.1093/rheumatology/keaf395

PMID:40795382

Abstract

OBJECTIVES

The relationship between dietary mineral intakes and the risk of rheumatoid arthritis (RA) remains limited. This study aims to investigate the associations between dietary mineral intakes with RA.

METHODS

We evaluated the association between dietary mineral intakes and RA in 123 940 adults age 40-70 years. The observation period extended from April 2009 to December 2019, encompassing individuals who had no prior diagnoses of RA. This study selected common minerals from the UK Biobank and NHANES datasets for analysis, including calcium, iron, potassium, magnesium, zinc, phosphorus, copper, sodium, and selenium. Cox proportional hazard models were performed to assess the association between dietary mineral intakes and RA in UK Biobank. Additionally, we validated the observed associations in NHANES to confirm the robustness.

RESULTS

After a median follow-up period of 8.07 years, a total of 123 940 participants were included in this study. The high intakes of iron (HR = 0.804, 95% CI 0.687-0.940) and magnesium (HR = 0.823, 95% CI 0.704-0.962) were associated with a reduced risk of RA. Intakes of phosphorus (HRMiddle = 0.827, 95% CI 0.707-0.966, HRHigh = 0.794, 95% CI 0.679-0.928) and copper (HRMiddle = 0.819, 95% CI 0.702-0.955, HRHigh = 0.763, 95% CI 0.652-0.893) were inversely associated with risk of RA. Similar results were observed in NHANES, particularly iron, magnesium, phosphorus, and copper.

CONCLUSION

This study supported that dietary mineral intakes were inversely associated with RA, particularly dietary iron, magnesium, phosphorus, and copper.

摘要

目的

膳食矿物质摄入量与类风湿关节炎（RA）风险之间的关系仍不明确。本研究旨在调查膳食矿物质摄入量与RA之间的关联。

方法

我们评估了123940名40 - 70岁成年人的膳食矿物质摄入量与RA之间的关联。观察期从2009年4月延长至2019年12月，涵盖之前未被诊断为RA的个体。本研究从英国生物银行和美国国家健康与营养检查调查（NHANES）数据集中选取常见矿物质进行分析，包括钙、铁、钾、镁、锌、磷、铜、钠和硒。采用Cox比例风险模型评估英国生物银行中膳食矿物质摄入量与RA之间的关联。此外，我们在NHANES中验证了观察到的关联以确认其稳健性。

结果

在中位随访期8.07年后，本研究共纳入123940名参与者。铁（HR = 0.804，95%CI 0.687 - 0.940）和镁（HR = 0.823，95%CI 0.704 - 0.962）的高摄入量与RA风险降低相关。磷（HR中 = 0.827，95%CI 0.707 - 0.966，HR高 = 0.794，95%CI 0.679 - 0.928）和铜（HR中 = 0.819，95%CI 0.702 - 0.955，HR高 = 0.763，95%CI 0.652 - 0.893）的摄入量与RA风险呈负相关。在NHANES中观察到了类似结果，特别是铁、镁、磷和铜。