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致编辑的信：预后生物标志物PSMD14通过调节核仁素-YAP1轴促进膀胱癌的发生和发展。

Letter to the editor: Prognostic biomarker PSMD14 facilitates bladder cancer tumorigenesis and progression by regulating Nucleolin-YAP1 axis.

作者信息

Han Yongzheng, Liu Chang, Wu Guangzhen

机构信息

Department of Urology, the First Affiliated Hospital of Dalian Medical University, Dalian, 116011, PR China.

Department of thoracic surgery, Shenyang Tenth People's Hospital/Shenyang Chest Hospital, PR China.

出版信息

Transl Oncol. 2025 Aug 11;61:102498. doi: 10.1016/j.tranon.2025.102498.

DOI:10.1016/j.tranon.2025.102498
PMID:40795696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12358667/
Abstract

• PSMD14/NCL/YAP1 axis linked to PD-L1-mediated immune evasion in BCa. • Humanized mouse models advocated for PSMD14 immune microenvironment validation. • Proposed PSMD14-siRNA nanotherapy via clinically advanced delivery systems. • Integrated TCGA-spatial analysis revealing PSMD14′s role in BCa.

摘要

• PSMD14/NCL/YAP1轴与膀胱癌中PD-L1介导的免疫逃逸相关。

• 提倡使用人源化小鼠模型验证PSMD14免疫微环境。

• 提出通过临床先进的递送系统进行PSMD14-siRNA纳米治疗。

• 整合TCGA空间分析揭示PSMD14在膀胱癌中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39bf/12358667/2327a60b9baa/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39bf/12358667/2327a60b9baa/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39bf/12358667/2327a60b9baa/gr1.jpg

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本文引用的文献

1
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Transl Oncol. 2025 May;55:102370. doi: 10.1016/j.tranon.2025.102370. Epub 2025 Mar 22.
2
Tumor-associated macrophage enhances PD-L1-mediated immune escape of bladder cancer through PKM2 dimer-STAT3 complex nuclear translocation.肿瘤相关巨噬细胞通过 PKM2 二聚体-STAT3 复合物核转位增强膀胱癌中 PD-L1 介导的免疫逃逸。
Cancer Lett. 2024 Jul 1;593:216964. doi: 10.1016/j.canlet.2024.216964. Epub 2024 May 16.
3
YTHDF2-mediated circYAP1 drives immune escape and cancer progression through activating YAP1/TCF4-PD-L1 axis.
YTHDF2介导的环状YAP1通过激活YAP1/TCF4-PD-L1轴驱动免疫逃逸和癌症进展。
iScience. 2023 Dec 30;27(2):108779. doi: 10.1016/j.isci.2023.108779. eCollection 2024 Feb 16.
4
PSMD14 stabilizes estrogen signaling and facilitates breast cancer progression via deubiquitinating ERα.PSMD14 通过去泛素化 ERα 稳定雌激素信号传导并促进乳腺癌的进展。
Oncogene. 2024 Jan;43(4):248-264. doi: 10.1038/s41388-023-02905-1. Epub 2023 Nov 29.
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Clin Transl Oncol. 2021 Mar;23(3):450-458. doi: 10.1007/s12094-020-02439-y. Epub 2020 Jul 11.
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