致编辑的信：预后生物标志物PSMD14通过调节核仁素-YAP1轴促进膀胱癌的发生和发展。
Letter to the editor: Prognostic biomarker PSMD14 facilitates bladder cancer tumorigenesis and progression by regulating Nucleolin-YAP1 axis.
作者信息
Han Yongzheng, Liu Chang, Wu Guangzhen
机构信息
Department of Urology, the First Affiliated Hospital of Dalian Medical University, Dalian, 116011, PR China.
Department of thoracic surgery, Shenyang Tenth People's Hospital/Shenyang Chest Hospital, PR China.
出版信息
Transl Oncol. 2025 Aug 11;61:102498. doi: 10.1016/j.tranon.2025.102498.
Abstract
• PSMD14/NCL/YAP1 axis linked to PD-L1-mediated immune evasion in BCa. • Humanized mouse models advocated for PSMD14 immune microenvironment validation. • Proposed PSMD14-siRNA nanotherapy via clinically advanced delivery systems. • Integrated TCGA-spatial analysis revealing PSMD14′s role in BCa.
摘要
• PSMD14/NCL/YAP1轴与膀胱癌中PD-L1介导的免疫逃逸相关。
• 提倡使用人源化小鼠模型验证PSMD14免疫微环境。
• 提出通过临床先进的递送系统进行PSMD14-siRNA纳米治疗。
• 整合TCGA空间分析揭示PSMD14在膀胱癌中的作用。
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