Buchar E, Janku I
Methods Find Exp Clin Pharmacol. 1985 Sep;7(9):469-72.
Rats given a single subdermal injection into the left hind paw of 0.5 mg Mycobacterium tuberculosis suspended in 0.1 ml of mineral oil, after several days of latency, developed arthritis accompanied by depression in liver microsomal phosphatidylcholine and phosphatidylethanolamine synthesis at 7, 14 and 21 days. The depression of liver microsomal phosphatidylcholine and phosphatidylethanolamine concentrations of experimental animals was accompanied by decreased incorporation of radioactive palmitate into both phospholipids. Nevertheless, the biosynthesis of phosphatidylcholine via the methylation pathway was unaffected. These observations suggest that adjuvant arthritis affects quantitatively the phospholipid composition of the liver endoplasmic reticulum, which consequently may lead to impairment of the microsomal drug-metabolizing enzyme system.
给大鼠左后爪皮下注射0.1 ml矿物油中悬浮的0.5 mg结核分枝杆菌，经过几天的潜伏期后，大鼠会患上关节炎，同时在第7、14和21天肝脏微粒体磷脂酰胆碱和磷脂酰乙醇胺合成出现抑制。实验动物肝脏微粒体磷脂酰胆碱和磷脂酰乙醇胺浓度降低，同时放射性棕榈酸掺入这两种磷脂的量也减少。然而，通过甲基化途径的磷脂酰胆碱生物合成未受影响。这些观察结果表明，佐剂性关节炎会定量影响肝脏内质网的磷脂组成，进而可能导致微粒体药物代谢酶系统受损。
