Effects of riboflavin administration on the phospholipid metabolism of rat liver impaired with carbon tetrachloride.

This study was undertaken to investigate the effects of riboflavin administration on the phospholipid metabolism of rat liver impaired with carbon tetrachloride. Although the specific radioactivity in the CCl4 group decreased, the groups pretreated with riboflavin, especially B2-butyrate group, were prevented a decrease of 32P incorporation into total phospholipid in liver. The percentage of 32P incorporation into phosphatidylcholine in both mitochondria and microsomes was increased by the administration of riboflavin.