Brown D W, Henkelman R M, Poon P Y, Fisher M M
Magn Reson Imaging. 1985;3(3):275-82. doi: 10.1016/0730-725x(85)90357-1.
Whole-tissue and homogenized samples of human liver were studied in a NMR spectrometer, T1 and T2 relaxation times were measured as a function of added inorganic or organic iron. When inorganic iron (Fe+3) was added, pronounced T1 and T2 shortening was noted. However, when organic iron, in the form of ferritin, was added, the amount of T1 and T2 relaxation enhancement was much reduced for the same amount of added iron. The in vitro ferritin results model the situation found in clinical studies of hemochromatosis. Only in cases of severe iron overload were significant decreases in relaxation times observed. The T2 relaxation time was the more reliable indicator of excessive levels of iron in the liver. The large range of T1 and T2 values encountered in normal volunteers precludes the use of MR to quantitatively measure iron levels in the liver. The T1 and T2 relaxation times measured at intervals for one individual tend to fluctuate as well, making the use of MR to follow the course of treatment of iron overload disorders unreliable.
对人肝脏的全组织和匀浆样本在核磁共振波谱仪中进行研究，测量了T1和T2弛豫时间与添加的无机铁或有机铁的函数关系。当添加无机铁（Fe+3）时，观察到明显的T1和T2缩短。然而，当以铁蛋白形式添加有机铁时，对于相同添加量的铁，T1和T2弛豫增强的量大大减少。体外铁蛋白结果模拟了血色素沉着症临床研究中发现的情况。仅在严重铁过载的情况下观察到弛豫时间有显著降低。T2弛豫时间是肝脏中铁过量水平更可靠的指标。正常志愿者中T1和T2值的大范围变化使得无法使用磁共振成像定量测量肝脏中的铁水平。对一个个体间隔测量的T1和T2弛豫时间也往往会波动，这使得使用磁共振成像跟踪铁过载疾病的治疗过程不可靠。
