Li Shisen, Xie Mianjiao, Du Yongtao, Tan Zhaobang
Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, China.
Department of Experimental Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Cell Commun Signal. 2025 Aug 12;23(1):369. doi: 10.1186/s12964-025-02235-7.
Chemo-resistance is one of the main obstacles in the treatment of colorectal cancer. Many studies have been performed to identify the mechanisms associated with chemo-resistance in colorectal cancer cells, and it has been found that increasing the activity of ABC family transporters, enhancing DNA repair, weakening apoptosis, strengthening stemness, and EMT are among the most important of these mechanisms. Inflammation and cytokines have been linked to colorectal cancer, and there is even a type of colorectal cancer that is caused by chronic inflammation in patients with inflammatory bowel disease. However, the association between cytokines and chemo-resistance in colorectal cancer cells is not yet clear. Various studies have shown that chemotherapy drugs, by affecting the tumor microenvironment, can enhance the recruitment of some immune cells and the production of some cytokines. These cytokines have a variety of effects on various chemo-resistance mechanisms in colorectal cancer cells. Some of them can strengthen chemo-resistance and others weaken chemo-resistance. IL-6, TNFα, IFN, IL1, IL8, IL-17, IL-10, and IL-22 are among the most important cytokines whose effects on chemo-resistance mechanisms in colorectal cancer cells are known. In this article, we will have a comprehensive overview of the effects of these cytokines on chemo-resistance mechanisms in colorectal cancer cells.
化疗耐药是结直肠癌治疗中的主要障碍之一。已经进行了许多研究来确定与结直肠癌细胞化疗耐药相关的机制，并且发现增加ABC家族转运蛋白的活性、增强DNA修复、减弱凋亡、强化干性以及上皮-间质转化是这些机制中最重要的部分。炎症和细胞因子与结直肠癌有关，甚至有一种结直肠癌是由炎症性肠病患者的慢性炎症引起的。然而，细胞因子与结直肠癌细胞化疗耐药之间的关联尚不清楚。各种研究表明，化疗药物通过影响肿瘤微环境，可以增强一些免疫细胞的募集和一些细胞因子的产生。这些细胞因子对结直肠癌细胞的各种化疗耐药机制有多种影响。其中一些可以增强化疗耐药性，而另一些则减弱化疗耐药性。白细胞介素-6（IL-6）、肿瘤坏死因子α（TNFα）、干扰素（IFN）、白细胞介素-1（IL1）、白细胞介素-8（IL8）、白细胞介素-17（IL-17）、白细胞介素-10（IL-10）和白细胞介素-22（IL-22）是已知对结直肠癌细胞化疗耐药机制有影响的最重要的细胞因子。在本文中，我们将全面概述这些细胞因子对结直肠癌细胞化疗耐药机制的影响。
