Cao Shen, Wang Yuhan, Tai Yi, Han Jing, Zheng Yanjin, Wang Can, Zuo Hong Xiang, Li Ming Yue, Xing Yue, Jin Xuejun, Ma Juan
Molecular Medicine Research Center, College of Pharmacy, Ministry of Education Key Laboratory of Changbai Mountain Natural Resources and Functional Molecules), Yanbian University, Yanji, 133002, Jilin Province, China.
Affiliated Hospital of Yanbian University (Yanbian Hospital), Yanji, China.
Inflammopharmacology. 2025 Aug 12. doi: 10.1007/s10787-025-01898-5.
Ulcerative colitis (UC) is an inflammatory disease characterized by lifelong involvement and a complex pathogenesis. Due to the limitations of current treatment modalities, there remains a pressing need to discover new medications for the management of UC. Cucurbitacin B (CuB) is a tetracyclic triterpenoid derived from Lagenaria siceraria (Molina) Standl., exhibiting pharmacological activities including hepatoprotective, anti-inflammatory, and anti-tumor properties. In this study, we conducted a comprehensive evaluation of the anti-inflammatory activity of CuB in both DSS-induced experimental colitis in vivo and macrophage models in vitro. Our results indicate that CuB exerts an anti-inflammatory effect by regulating the assembly of the NLRP3 inflammasome and the activation of p-STAT3 via ZNF70, thereby reducing the release of pro-inflammatory cytokines, including IL-1β, IL-6, and TNF-α. Such results indicate that CuB can effectively prevent the development of UC and offer new insights for its management.
溃疡性结肠炎（UC）是一种以终身受累和复杂发病机制为特征的炎症性疾病。由于目前治疗方式的局限性，仍然迫切需要发现用于治疗UC的新药物。葫芦素B（CuB）是一种从葫芦（Molina）Standl.中提取的四环三萜类化合物，具有保肝、抗炎和抗肿瘤等药理活性。在本研究中，我们对CuB在葡聚糖硫酸钠（DSS）诱导的体内实验性结肠炎和体外巨噬细胞模型中的抗炎活性进行了全面评估。我们的结果表明，CuB通过调节NLRP3炎性小体的组装和经由锌指蛋白70（ZNF70）激活p-STAT3，从而减少包括白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）在内的促炎细胞因子的释放，发挥抗炎作用。这些结果表明，CuB可以有效预防UC的发展，并为其治疗提供新的见解。
