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先天性下腔静脉缺如,青少年深静脉血栓形成的罕见原因:病例报告。

Congenital absence of the inferior vena cava, a rare cause of deep vein thrombosis in adolescent: Case report.

作者信息

Im Dongwon, Kang Ayoung, Kim Soo-Hong, Lee Sang Su, Jung Hyuk Jae

机构信息

Department of Surgery, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do, Republic of Korea.

School of Medicine, Pusan National University, Busan, Republic of Korea.

出版信息

Medicine (Baltimore). 2025 Aug 8;104(32):e43818. doi: 10.1097/MD.0000000000043818.

DOI:10.1097/MD.0000000000043818
PMID:40797449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12338225/
Abstract

RATIONALE

Deep vein thrombosis (DVT) is rare in pediatric patients. Congenital inferior vena cava (IVC) anomalies are asymptomatic; however, these can cause DVT in younger patients rarely.

PATIENT CONCERNS

In this case, a 14-year-old male patient was referred to our hospital for lower abdominal pain.

DIAGNOSES

At the first hospital he visited, computed tomography revealed a thrombus in the veins of the abdomen and lower extremities; however, an accurate diagnosis could not be made because the thrombus was thought to be inconsistent with abdominal pain. Close examinations revealed swelling of the lower extremities and pain while walking. Contrast-enhanced computed tomography revealed the absence of IVC (AIVC), resulting in DVT at the external iliac, gonadal, inferior mesenteric, and collateral veins of the right pelvic cavity.

INTERVENTIONS

The patient received anticoagulation therapy.

OUTCOMES

At a follow-up 6 months later, his symptoms improved, and a thrombus was not found. AIVC could cause DVT.

LESSONS

DVT is rare in pediatric patients and is difficult to diagnose when the initial symptoms are vague. Conservative treatments are the most commonly used treatment; long-term follow-up is needed.

摘要

理论依据

小儿深静脉血栓形成(DVT)较为罕见。先天性下腔静脉(IVC)异常通常无症状;然而,这些异常在年轻患者中极少会导致DVT。

患者情况

在本病例中,一名14岁男性患者因下腹部疼痛被转诊至我院。

诊断

在他最初就诊的医院,计算机断层扫描显示腹部和下肢静脉有血栓形成;然而,由于认为该血栓与腹痛不符,无法做出准确诊断。进一步检查发现下肢肿胀且行走时疼痛。增强计算机断层扫描显示下腔静脉缺如(AIVC),导致右侧盆腔髂外静脉、性腺静脉、肠系膜下静脉及侧支静脉出现DVT。

干预措施

患者接受了抗凝治疗。

治疗结果

6个月后的随访中,其症状有所改善,未发现血栓。AIVC可导致DVT。

经验教训

小儿DVT罕见,初始症状不明确时难以诊断。保守治疗是最常用的治疗方法;需要长期随访。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c14/12338225/21594e63c7aa/medi-104-e43818-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c14/12338225/1a6895ba95c7/medi-104-e43818-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c14/12338225/6e9965765705/medi-104-e43818-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c14/12338225/885eaef06b15/medi-104-e43818-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c14/12338225/21594e63c7aa/medi-104-e43818-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c14/12338225/1a6895ba95c7/medi-104-e43818-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c14/12338225/6e9965765705/medi-104-e43818-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c14/12338225/885eaef06b15/medi-104-e43818-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c14/12338225/21594e63c7aa/medi-104-e43818-g004.jpg

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本文引用的文献

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Vena Cava Atresia and Deep Vein Thrombosis: A Case Report and Systematic Review.腔静脉闭锁与深静脉血栓形成:一例报告及系统评价
Int J Angiol. 2021 Jul 30;31(2):88-91. doi: 10.1055/s-0041-1732434. eCollection 2022 Jun.
2
Extensive deep venous thrombosis in a young male with absent infrarenal inferior vena cava.一名年轻男性出现广泛的深静脉血栓形成,其肾下下腔静脉缺如。
J Vasc Surg Cases Innov Tech. 2022 Jan 26;8(2):146-150. doi: 10.1016/j.jvscit.2022.01.001. eCollection 2022 Jun.
3
Anomalies of Inferior Vena Cava: Implications and Considerations in Retroperitoneal Surgical Procedures.
下腔静脉异常:腹膜后手术中的影响与考量
Ann Vasc Surg. 2022 Feb;79:372-379. doi: 10.1016/j.avsg.2021.07.029. Epub 2021 Oct 10.
4
An Eminent Absence: Agenesis of Inferior Vena Cava Underlying Bilateral Iliac Vein Thrombosis.显著缺失:双侧髂静脉血栓形成的潜在原因——下腔静脉缺如
Eur J Case Rep Intern Med. 2020 Oct 22;7(12):001999. doi: 10.12890/2020_001999. eCollection 2020.
5
Various congenital anomalies of the inferior vena cava: review of cross-sectional imaging findings and report of a new variant.下腔静脉各种先天性异常:影像学表现回顾及一种新变异型的报告。
Abdom Radiol (NY). 2018 Aug;43(8):2130-2149. doi: 10.1007/s00261-017-1430-y.
6
Congenital absence of inferior vena cava: an under recognised cause of unprovoked venous thromboembolism.先天性下腔静脉缺如:不明原因静脉血栓栓塞的一个未被充分认识的病因。
QJM. 2018 Feb 1;111(2):117-118. doi: 10.1093/qjmed/hcx225.
7
Congenital abnormalities of the inferior vena cava presenting clinically in adolescent males.青少年男性临床上出现的下腔静脉先天性异常。
Thromb Res. 2015 Apr;135(4):648-51. doi: 10.1016/j.thromres.2015.01.032. Epub 2015 Feb 7.
8
The clinical anatomy of the inferior vena cava: a review of common congenital anomalies and considerations for clinicians.下腔静脉的临床解剖学:常见先天性异常综述及临床医生的考量
Clin Anat. 2014 Nov;27(8):1234-43. doi: 10.1002/ca.22445. Epub 2014 Jul 17.