Lv Weiwei, Song Wenchong
TCM Pharmacy, Huang Gang Central Hospital Affiliated to Changjiang University, Huanggang, Hubei, China.
Division of Gastroenterology, Huang Gang Central Hospital Affiliated to Changjiang University, Huanggang, Hubei, China.
Medicine (Baltimore). 2025 Aug 8;104(32):e43543. doi: 10.1097/MD.0000000000043543.
Colorectal cancer (CRC) is one of the most common malignant tumors worldwide, and early diagnosis and prognostic assessment are crucial for improving patient survival. The ratio of platelet mean volume (MPV) to platelet count (PC) (MPV/PC) has been proposed as a potential diagnostic biomarker for tumors. A total of 321 participants were included in this study, with 204 in the CRC group and 117 in the control group. By comparing the baseline characteristics of the 2 groups, the application of MPV/PC ratio in CRC diagnosis and its association with clinical pathological features were analyzed. Receiver operating characteristic curve analysis was used to assess the diagnostic efficacy of MPV/PC ratio, and multivariate regression analysis was performed to explore its role in postoperative recurrence risk assessment. The MPV/PC ratio in the CRC group was significantly higher than that in the control group (P < .001). The average age was 62.7 years in the CRC group and 60.5 years in the control group, with a male proportion of 56.4% and 52.1%, respectively. The area under the curve of MPV/PC ratio was 0.802, with a sensitivity of 76.5% and specificity of 78.3%, showing good diagnostic efficacy. High MPV/PC ratio was closely associated with unfavorable prognostic factors such as lymph node metastasis, TNM stage, and carcinoembryonic antigen levels. MPV/PC ratio was identified as an independent risk factor for CRC and effectively predicted postoperative recurrence risk (hazard ratio = 2.12, P = .002). The MPV/PC ratio is a simple, low-cost, and effective biomarker that provides important reference value in the early screening, diagnosis, prognostic evaluation, and postoperative recurrence risk prediction of CRC. It has broad potential as a clinical tool and warrants further research and validation.
结直肠癌（CRC）是全球最常见的恶性肿瘤之一，早期诊断和预后评估对于提高患者生存率至关重要。血小板平均体积（MPV）与血小板计数（PC）之比（MPV/PC）已被提出作为一种潜在的肿瘤诊断生物标志物。本研究共纳入321名参与者，其中CRC组204名，对照组117名。通过比较两组的基线特征，分析MPV/PC比值在CRC诊断中的应用及其与临床病理特征的关系。采用受试者工作特征曲线分析评估MPV/PC比值的诊断效能，并进行多因素回归分析以探讨其在术后复发风险评估中的作用。CRC组的MPV/PC比值显著高于对照组（P < 0.001）。CRC组的平均年龄为62.7岁，对照组为60.5岁，男性比例分别为56.4%和52.1%。MPV/PC比值的曲线下面积为0.802，灵敏度为76.5%，特异度为78.3%，显示出良好的诊断效能。高MPV/PC比值与淋巴结转移、TNM分期和癌胚抗原水平等不良预后因素密切相关。MPV/PC比值被确定为CRC的独立危险因素，并有效预测术后复发风险（风险比 = 2.12，P = 0.002）。MPV/PC比值是一种简单、低成本且有效的生物标志物，在CRC的早期筛查、诊断、预后评估和术后复发风险预测中具有重要参考价值。它作为一种临床工具具有广阔的潜力，值得进一步研究和验证。
