Zhang Yanan, Yue Yumeng, Zhao Zongxing, Liu Haifeng
Department of Geriatrics, Liaocheng People's Hospital, Liaocheng, Shandong, China.
Department of Radiation Oncology, Liaocheng People's Hospital, Liaocheng, Shandong, China.
Front Oncol. 2025 Jul 29;15:1579029. doi: 10.3389/fonc.2025.1579029. eCollection 2025.
Mediastinal lymph node metastasis from squamous cell carcinoma (SCC) is one of the most common sites for regional metastasis in thoracic malignancies. However, SCC originating from the ileum is relatively rare. We herein report a case of mediastinal lymph node metastasis as the first manifestation of postoperative ileal SCC. No primary tumor was detected on comprehensive imaging studies and bronchoscopy in this patient, and endobronchial ultrasound (E-BUS) considered metastatic SCC. After undergoing four cycles of postoperative chemotherapy with the XELOX regimen, the patient experienced rapid disease progression; however, a subsequent change to a treatment regimen of paclitaxel and cisplatin resulted in a favorable response. This article details the patient's clinical presentation and treatment course and includes a literature review of primary SCCs arising from the jejunum and ileum, thereby enhancing understanding of these uncommon small intestine tumors.
鳞状细胞癌（SCC）的纵隔淋巴结转移是胸部恶性肿瘤区域转移最常见的部位之一。然而，起源于回肠的SCC相对罕见。我们在此报告一例纵隔淋巴结转移作为术后回肠SCC的首发表现。该患者经全面影像学检查和支气管镜检查未发现原发性肿瘤，而支气管内超声（E-BUS）考虑为转移性SCC。患者接受XELOX方案术后化疗四个周期后，疾病迅速进展；然而，随后改为紫杉醇和顺铂治疗方案后产生了良好反应。本文详细介绍了患者的临床表现和治疗过程，并对空肠和回肠原发性SCC进行了文献综述，从而增进了对这些罕见小肠肿瘤的认识。
