Shinohara Koh, Tsuda Yusuke, Tsuchido Yasuhiro, Yamamoto Masaki, Matsumura Yasufumi, Nagao Miki
Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Open Forum Infect Dis. 2025 Jul 8;12(8):ofaf406. doi: 10.1093/ofid/ofaf406. eCollection 2025 Aug.
Despite growing concerns about the invasiveness of infections in patients with comorbidities, the clinical features of campylobacteriosis in immunocompromised hosts remain unclear.
We conducted a retrospective cohort study on campylobacteriosis to investigate the clinical features of patients with immunosuppressive conditions in a university hospital in Japan between 2010 and 2023. The patients were classified into immunocompetent and immunocompromised groups. The clinical characteristics of the disease were compared between the groups.
In total, 200 patients were included: 126 in the immunocompetent group and 74 in the immunocompromised group. Patients in the immunocompromised group were significantly associated with bacteremia, especially hematopoietic stem cell transplant recipients, those with hematological malignancies, and those who received chemotherapy or steroids. Among cases with enteritis, compared with the immunocompetent group, the immunocompromised group was more likely to lack bloody stool. Prolonged duration of diarrhea over 30 days was observed in 6% of cases with diarrhea and was associated with hematological malignancy, receipt of chemotherapy, low immunoglobulin G level, and the use of rituximab. Concomitant infection with cytomegalovirus was commonly seen among cases with a prolonged duration of diarrhea.
Our findings indicate that the clinical presentation of campylobacteriosis is affected by the patients' immune status.
尽管对合并症患者感染的侵袭性日益担忧，但免疫功能低下宿主弯曲菌病的临床特征仍不清楚。
我们对弯曲菌病进行了一项回顾性队列研究，以调查2010年至2023年期间日本一家大学医院免疫抑制患者的临床特征。患者分为免疫功能正常组和免疫功能低下组。比较两组疾病的临床特征。
共纳入200例患者：免疫功能正常组126例，免疫功能低下组74例。免疫功能低下组患者与菌血症显著相关，尤其是造血干细胞移植受者、血液系统恶性肿瘤患者以及接受化疗或使用类固醇的患者。在肠炎病例中，与免疫功能正常组相比，免疫功能低下组更易无血便。6%的腹泻病例观察到腹泻持续时间超过30天，这与血液系统恶性肿瘤、接受化疗、低免疫球蛋白G水平以及使用利妥昔单抗有关。腹泻持续时间延长的病例中常见巨细胞病毒合并感染。
我们的研究结果表明，弯曲菌病的临床表现受患者免疫状态的影响。
