Carter W H, Wampler G L, Crews S L, Howells R
Cancer Treat Rep. 1977 Aug;61(5):849-53.
This paper presents a statistical method for analyzing the dose response surface associated with treatments resulting from combinations of any number of cytotoxic agents. The results of such an analysis are the dosages of each agent in the combination which will maximize the probability of a favorable response. An example utilizing a combination of hexamethylmelamine and ICRF-159 is presented. The predictive ability of the model is verified by a kappa 2 goodness of fit test. The advantages of such a method relate to its potential applicability to more complex experimental situations where multiple drugs are used in combination and/or where variations in timing of drug administration exist.
本文提出了一种统计方法，用于分析与任意数量细胞毒性药物组合产生的治疗相关的剂量反应面。这种分析的结果是组合中每种药物的剂量，该剂量将使产生良好反应的概率最大化。给出了一个使用六甲蜜胺和ICRF - 159组合的示例。通过kappa 2拟合优度检验验证了该模型的预测能力。这种方法的优点在于其潜在适用于更复杂的实验情况，即在联合使用多种药物和/或存在药物给药时间变化的情况下。
