在威尔士一家急症医院爆发新冠疫情期间，疫苗接种及医疗救治获取在呼吸衰竭中所起的作用。
The role of vaccination and healthcare acquisition in respiratory failure during a COVID-19 outbreak in an acute hospital in Wales.
作者信息
Hogg Craig, McKerr Caoimhe, Craine Noel, Williams Dafydd, Perry Malorie, Cottrell Simon
机构信息
Communicable Disease Surveillance Centre, Public Health Wales, Cardiff, Wales, UK.
Infection Prevention Department, Ysbyty Gwynedd, Betsi Cadwaladr University Health Board, Bangor, Wales, UK.
出版信息
Infect Prev Pract. 2025 Jul 9;7(3):100474. doi: 10.1016/j.infpip.2025.100474. eCollection 2025 Sep.
This study provides descriptive analysis of a COVID-19 outbreak of 323 cases in a Welsh hospital in early 2021, with a focus on respiratory failure (RF) as a severe outcome. Multivariate analysis demonstrated decreased odds of RF in healthcare acquired cases (aOR 0.40 (95%CI 0.24-0.65), <0.001) and individuals with at least one dose of vaccine 14 days before first positive test (aOR 0.45 (95%CI 0.28-0.75), =0.002). In healthcare acquired cases, vaccination significantly reduced the odds of RF (OR 0.47 (95%CI 0.22-0.00), =0.037). This analysis highlights the importance of vaccination as a protective factor against severe respiratory outcomes.
本研究对2021年初威尔士一家医院发生的323例新冠肺炎疫情进行了描述性分析，重点关注呼吸衰竭（RF）这一严重后果。多变量分析表明，医院获得性感染病例发生呼吸衰竭的几率降低（调整后比值比为0.40（95%置信区间为0.24 - 0.65），P<0.001），以及在首次检测呈阳性前14天至少接种一剂疫苗的个体（调整后比值比为0.45（95%置信区间为0.28 - 0.75），P = 0.002）。在医院获得性感染病例中，接种疫苗显著降低了呼吸衰竭的几率（比值比为0.47（95%置信区间为0.22 - 0.00），P = 0.037）。该分析突出了接种疫苗作为预防严重呼吸后果保护因素的重要性。
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