Kellogg C K, Simmons R D, Miller R K, Ison J R
Neurobehav Toxicol Teratol. 1985 Sep-Oct;7(5):483-8.
Adult (90-100 day-old) rats exposed prenatally (13-20 days of gestation) to diazepam (DZ) at 1.0, 2.5, or 10 mg/kg/day, were examined for functional deficits. Tests were designed to (1) correlate with known neural alterations induced by the prenatal exposure, or (2) to address the problem of developing tests of functional teratology in animals which have relevance to complex human functions. The careful selection of functional tests has disclosed several effects of prenatal DZ exposure on adult rat progeny. The dose-effect relationship was found to vary with the different tests, indicating that a thorough evaluation of the consequences of prenatal drug exposure necessitates utilization of several functional approaches. The results of these studies on the effects of prenatal exposure to DZ support the hypothesis that in utero exposure to drugs targeted for action on the central nervous system can induce long-lasting alterations on the neural substrates of behavior on the offspring with resulting functional consequences.
将孕期（妊娠第13 - 20天）暴露于1.0、2.5或10毫克/千克/天剂量地西泮（DZ）的成年（90 - 100日龄）大鼠进行功能缺陷检测。测试旨在：（1）与产前暴露引起的已知神经改变相关联，或（2）解决开发与复杂人类功能相关的动物功能致畸学测试问题。功能测试的精心选择揭示了产前暴露于DZ对成年大鼠后代的若干影响。发现剂量 - 效应关系因不同测试而异，这表明对产前药物暴露后果的全面评估需要采用多种功能方法。这些关于产前暴露于DZ影响的研究结果支持以下假设：子宫内暴露于作用于中枢神经系统的药物可导致后代行为神经基质的长期改变，并产生功能后果。
