用于快速、无导航器的亚毫米扩散磁共振成像且减少层边界信号损失的伪分区编码同时多层面成像(pPRISM)。

Pseudo partition-encoded simultaneous multislab (pPRISM) for rapid, navigator-free submillimeter diffusion MRI with reduced slab-boundary signal loss.

作者信息

Chang Wei-Tang, Liao Congyu, Lee Hong-Hsi

机构信息

Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

出版信息

Imaging Neurosci (Camb). 2025 Jan 3;3. doi: 10.1162/imag_a_00417. eCollection 2025.

Abstract

The primary aim of this study is to address the challenges in submillimeter diffusion magnetic resonance imaging (dMRI), such as prolonged acquisition time, low signal-to-noise ratio (SNR), and signal attenuation at slab boundary. We introduce a novel 3D Fourier encoding mechanism, PRISM (Partition-encoded Simultaneous Multislab), and a new concept termed "pseudo slab." The PRISM method allows simultaneous inter-slab and intra-slab Fourier encoding solely using the slice gradient, eliminating the need for RF encoding. The pseudo slab concept not only minimizes inter-slab signal leakage and Gibbs truncation artifacts, but also enables phase scheduling onto intra-slab slices, thus eliminating the need for a phase navigator and time-varying gradient such as variable-rate selective excitation (VERSE). Integrating the pseudo slab with PRISM, the resulting pseudo PRISM (pPRISM) technique achieved rapid acquisition of dMRI with 0.86-mm isotropic resolution and an effective TR of 12 s (TR of 2.4 s per shot). Compared to Generalized Slice Dithered Enhanced Resolution with Simultaneous Multislice (gSlider-SMS), the shortened acquisition time improved the SNR efficiency without aggravating the signal attenuation at slab boundaries. The robustness of pPRISM against field inhomogeneity was also supported by Bloch simulation and empirical data. Furthermore, dMRI was successfully achieved with a 0.76-mm isotropic resolution, an effective TR of 15 s, and b-values of up to 2500 s/mm. The ultrahigh-resolution results of the proposed pPRISM method demonstrated the anticipated dark bands of fractional anisotropy (FA) at gray-white matter boundaries and yielded more plausible tractography results. Our pPRISM framework paves the way for acquiring ultrahigh-resolution dMRI in clinically feasible times, advancing microstructural research.

摘要

本研究的主要目的是解决亚毫米扩散磁共振成像(dMRI)中的挑战,例如采集时间延长、低信噪比(SNR)以及层面边界处的信号衰减。我们引入了一种新颖的3D傅里叶编码机制PRISM(分区编码同时多层)以及一个名为“伪层面”的新概念。PRISM方法仅使用层面梯度就允许同时进行层面间和层面内的傅里叶编码,无需射频编码。伪层面概念不仅能最小化层面间信号泄漏和吉布斯截断伪影,还能在层面内切片上进行相位调度,从而无需相位导航器和诸如可变率选择性激发(VERSE)等时变梯度。将伪层面与PRISM相结合,所得的伪PRISM(pPRISM)技术实现了以0.86毫米各向同性分辨率和12秒的有效重复时间(TR)(每次采集TR为2.4秒)快速采集dMRI。与同时多层广义切片抖动增强分辨率(gSlider-SMS)相比,缩短的采集时间提高了SNR效率,而不会加剧层面边界处的信号衰减。Bloch模拟和经验数据也支持了pPRISM对场不均匀性的鲁棒性。此外,还成功实现了以0.76毫米各向同性分辨率、15秒的有效TR和高达2500 s/mm²的b值进行dMRI。所提出的pPRISM方法的超高分辨率结果显示了灰-白质边界处预期的分数各向异性(FA)暗带,并产生了更合理的纤维束成像结果。我们的pPRISM框架为在临床可行的时间内获取超高分辨率dMRI铺平了道路,推动了微观结构研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89e4/12301896/eab812735a3e/imag_a_00417_fig1.jpg

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