Yu An, Ma Changguo, Hu Min
Yunnan Key Laboratory of Cell Therapy for Refractory Diseases, Kunming University, Kunming 650214, China.
Cells. 2025 Jul 25;14(15):1153. doi: 10.3390/cells14151153.
The growing global elderly population underscores the escalating importance of anti-aging interventions to combat age-related diseases and extend both health span and lifespan. Over the past decades, various anti-aging interventions have gained recognition, each with its unique set of advantages and limitations. Notably, the transplantation of rejuvenated autologous adult stem cells is standing out as a powerful strategy that holds significant promise in combating age-related functional decline and diseases. This review delves into our current biological insights into cellular rejuvenation and provides an overview of both pre-clinical and clinical experiences with autologous and allogeneic adult stem cell transplantations. It reinforces the concept that rejuvenated adult stem cells constitute a pivotal element in the quest for the fountain of youth. Additionally, we examine the technical challenges involved in obtaining and utilizing these rejuvenated adult stem cells.
全球老年人口的不断增长凸显了抗衰老干预措施对于对抗与年龄相关疾病以及延长健康寿命和寿命的重要性日益增加。在过去几十年中，各种抗衰老干预措施已得到认可，每种措施都有其独特的优势和局限性。值得注意的是，回春后的自体成体干细胞移植作为一种强大的策略脱颖而出，在对抗与年龄相关的功能衰退和疾病方面具有重大前景。本综述深入探讨了我们目前对细胞回春的生物学见解，并概述了自体和异体成体干细胞移植的临床前和临床经验。它强化了这样一个概念，即回春后的成体干细胞是追求青春源泉的关键要素。此外，我们研究了获取和利用这些回春后的成体干细胞所涉及的技术挑战。
