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腱生蛋白的抗生肌作用及其被表没食子儿茶素-3-没食子酸酯抑制后可增强肌生成。

The Anti-Myogenic Role of Tetranectin and Its Inhibition by Epigallocatechin-3-Gallate Enhances Myogenesis.

作者信息

Akash Amar, Kim Jihoe

机构信息

Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Republic of Korea.

出版信息

Cells. 2025 Jul 28;14(15):1160. doi: 10.3390/cells14151160.

DOI:10.3390/cells14151160
PMID:40801593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12346571/
Abstract

Tetranectin (TN) is a plasminogen-binding protein found in human serum. Although it has been suggested to be closely related to various stem cell differentiation, including myogenesis, the role of TN in muscle development remains unclear. In this study, we identified TN as an anti-myogenic factor during the differentiation of C2C12 satellite cells. The exogenous supplementation of TN inhibited myogenic differentiation, whereas differentiation was significantly enhanced in the TN-depleted medium. Epigallocatechin-3-gallate (EGCG), a catechin abundant in green tea, significantly enhanced myogenic differentiation by reducing TN levels in the medium and downregulating TN gene expression during the differentiation process. These results demonstrate that EGCG promotes myogenesis by inhibiting TN at both the transcriptional and functional levels, highlighting TN as a promising therapeutic target for muscle regeneration disorders.

摘要

纤连蛋白（TN）是一种在人血清中发现的纤溶酶原结合蛋白。尽管有人认为它与包括肌生成在内的各种干细胞分化密切相关，但TN在肌肉发育中的作用仍不清楚。在本研究中，我们确定TN是C2C12卫星细胞分化过程中的一种抗肌生成因子。外源性补充TN可抑制肌生成分化，而在TN缺失的培养基中分化则显著增强。表没食子儿茶素-3-没食子酸酯（EGCG）是绿茶中丰富的一种儿茶素，通过降低培养基中TN水平并在分化过程中下调TN基因表达，显著增强了肌生成分化。这些结果表明，EGCG通过在转录和功能水平上抑制TN来促进肌生成，突出了TN作为肌肉再生障碍的一个有前景的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae86/12346571/1c8c1a950a09/cells-14-01160-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae86/12346571/9578ff1042c0/cells-14-01160-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae86/12346571/66703857b5ea/cells-14-01160-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae86/12346571/cd2c279aa41b/cells-14-01160-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae86/12346571/98cd04429b29/cells-14-01160-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae86/12346571/9678028fd965/cells-14-01160-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae86/12346571/ec917bf19dc2/cells-14-01160-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae86/12346571/1c8c1a950a09/cells-14-01160-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae86/12346571/9578ff1042c0/cells-14-01160-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae86/12346571/66703857b5ea/cells-14-01160-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae86/12346571/cd2c279aa41b/cells-14-01160-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae86/12346571/98cd04429b29/cells-14-01160-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae86/12346571/9678028fd965/cells-14-01160-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae86/12346571/ec917bf19dc2/cells-14-01160-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae86/12346571/1c8c1a950a09/cells-14-01160-g007.jpg

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本文引用的文献

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Int J Mol Sci. 2022 Dec 25;24(1):340. doi: 10.3390/ijms24010340.
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Tetranectin targeting by epigallocatechin gallate suppresses colon cancer cell proliferation.表没食子儿没食子酸酯靶向纤连蛋白四聚体可抑制结肠癌细胞增殖。
Int J Biol Macromol. 2022 Jun 1;209(Pt A):211-219. doi: 10.1016/j.ijbiomac.2022.03.160. Epub 2022 Mar 28.
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CLEC3B protects H9c2 cardiomyocytes from apoptosis caused by hypoxia via the PI3K/Akt pathway.
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Braz J Med Biol Res. 2020;53(9):e9693. doi: 10.1590/1414-431x20209693. Epub 2020 Jul 17.
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Tetranectin, a potential novel diagnostic biomarker of heart failure, is expressed within the myocardium and associates with cardiac fibrosis.腱糖蛋白，一种潜在的新型心力衰竭诊断生物标志物，在心内膜表达，并与心脏纤维化相关。
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