Serafini Patrick Tuzi, Brum Evelyne Silva, Becker Gabriela, Favarin Amanda, Brusco Indiara, Oliveira Sara Marchesan
Graduate Program in Biological Sciences: Toxicological Biochemistry, Centre of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Graduate Program in Biological Sciences: Biochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Aug 13. doi: 10.1007/s00210-025-04509-w.
Injuries resulting from sun exposure constitute a public health problem and are characterised by pain, oedema, and erythema. Although generally effective, the available drugs for treating burns cause adverse effects that limit their use, demonstrating the need for new pharmacological options. Natural products, such as oleic acid (OA), which are naturally present in cellular structures and the diet, appear promising therapeutic alternatives due to their antinociceptive, anti-inflammatory, and antioxidant actions. Thus, we evaluated the effects of topical OA (0.3%, 1%, and 3%) in a sunburn model induced by UVB radiation (0.75 J/cm) in mice and compared these effects with dexamethasone (Dex) 0.1%. We evaluated nociceptive parameters (mechanical allodynia, pain affective-motivational behaviour, and thermal hypersensitivity), inflammatory parameters (paw oedema formation and infiltration of polymorphonuclear cells), and reactive oxygen species levels in the mice's serum. OA (3%) attenuated mechanical allodynia (100% of inhibition), pain affective-motivational behaviour (72 ± 14.05% of inhibition), and thermal sensitivity (100% of inhibition). Furthermore, OA (3%) reduced paw oedema (58.18 ± 11% of inhibition) and polymorphonuclear infiltration (54.35 ± 10% of inhibition) in the mice's plantar tissue and reduced reactive oxygen species serum levels (100% of inhibition). Topical 0.1% Dex showed similar effects to OA on the analysed parameters. Our results suggest that OA is a promising therapeutic alternative for treating inflammatory conditions, such as sunburn.
阳光照射导致的损伤构成了一个公共卫生问题，其特征为疼痛、水肿和红斑。尽管用于治疗烧伤的现有药物通常有效，但它们会产生不良反应，限制了其使用，这表明需要新的药理学选择。天然产物，如油酸（OA），天然存在于细胞结构和饮食中，由于其具有抗伤害感受、抗炎和抗氧化作用，似乎是很有前景的治疗替代品。因此，我们评估了局部应用OA（0.3%、1%和3%）对小鼠中波紫外线（UVB）辐射（0.75 J/cm）诱导的晒伤模型的影响，并将这些影响与0.1%的地塞米松（Dex）进行比较。我们评估了伤害感受参数（机械性异常性疼痛、疼痛情感动机行为和热超敏反应）、炎症参数（爪部水肿形成和多形核细胞浸润）以及小鼠血清中的活性氧水平。OA（3%）减轻了机械性异常性疼痛（100%抑制）、疼痛情感动机行为（72±14.05%抑制）和热敏感性（100%抑制）。此外，OA（3%）减少了小鼠足底组织中的爪部水肿（58.18±11%抑制）和多形核细胞浸润（54.35±10%抑制），并降低了血清活性氧水平（100%抑制）。局部应用0.1%的Dex在分析的参数上显示出与OA相似的效果。我们的结果表明，OA是治疗晒伤等炎症性疾病的一种有前景的治疗替代品。
